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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

fabF

Organism
Bacillus subtilis BEST7613
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.UniRule annotation

Catalytic activityi

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei167UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2UniRule annotation (EC:2.3.1.179UniRule annotation)
Gene namesi
Name:fabFImported
ORF Names:BEST7613_2104Imported
OrganismiBacillus subtilis BEST7613Imported
Taxonomic identifieri1204343 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000011218 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliL8AHF7
SMRiL8AHF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 406PKS_KSInterPro annotationAdd BLAST398

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG091H018O

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR017568 3-oxoacyl-ACP_synth-2
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PIRSFiPIRSF000447 KAS_II, 1 hit
SMARTiView protein in SMART
SM00825 PKS_KS, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR03150 fabF, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

L8AHF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLEKKRVV VTGLGAITPI GNTLQDYWQG LMEGRNGIGP ITRFDASDQA
60 70 80 90 100
CRFGGEVKDF DATQFLDRKE AKRMDRFCHF AVCASQQAIN DAKLVINELN
110 120 130 140 150
ADEIGVLIGT GIGGLKVLED QQTILLDKGP SRCSPFMIPM MIANMASGLT
160 170 180 190 200
AINLGAKGPN NCTVTACAAG SNAIGDAFRL VQNGYAKAMI CGGTEAAITP
210 220 230 240 250
LSYAGFASAR ALSFRNDDPL HASRPFDKDR DGFVMGEGSG ILILEELESA
260 270 280 290 300
LARGAKIYGE MVGYAMTCDA YHITAPVPDG RGATRAIAWA LKDSGLKPEM
310 320 330 340 350
VSYINAHGTS TPANDVTETR AIKQALGNHA YNIAVSSTKS MTGHLLGGSG
360 370 380 390 400
GIEAVATVMA IAEDKVPPTI NLENPDPECD LDYVPGQSRA LIVDVALSNS
410
FGFGGHNVTL AFKKYQ
Length:416
Mass (Da):44,004
Last modified:April 3, 2013 - v1
Checksum:iB0740A438A91A6C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012495 Genomic DNA Translation: BAM51035.1

Genome annotation databases

EnsemblBacteriaiBAM51035; BAM51035; BEST7613_2104
PATRICifig|1148.72.peg.2255

Similar proteinsi

Entry informationi

Entry nameiL8AHF7_BACIU
AccessioniPrimary (citable) accession number: L8AHF7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: March 28, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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