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Protein

Thymidine kinase

Gene

tdk

Organism
Geobacillus sp. GHH01
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:GHH_c34760Imported
OrganismiGeobacillus sp. GHH01Imported
Taxonomic identifieri1233873 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000011251 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

L8A4Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVMTQSGWL ELICGCMFSG KSEELIRRVR RAQFAKQEVK VFKPTIDNRY
60 70 80 90 100
SEDAVVSHNG NSVIAIPVAT PAEMFRYISA ATDVVAIDEI QFFSDDIIDV
110 120 130 140 150
VQTLADCGYR VIAAGLDQDF RGEPFGPVPA LMAIAESVTK LQAVCTVCGS
160 170 180 190 200
PASRTQRLIN GAPASYDDPV ILVGASEAYE PRCRHHHEVP GKPKKRYNRP

LAGHTGE
Length:207
Mass (Da):22,717
Last modified:April 3, 2013 - v1
Checksum:i8D83B14DA96FB3A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP004008 Genomic DNA Translation: AGE23966.1
RefSeqiWP_014196962.1, NC_020210.1

Genome annotation databases

EnsemblBacteriaiAGE23966; AGE23966; GHH_c34760
GeneIDi32065265
KEGGiggh:GHH_c34760
PATRICifig|1233873.3.peg.3749

Similar proteinsi

Entry informationi

Entry nameiL8A4Q3_9BACI
AccessioniPrimary (citable) accession number: L8A4Q3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: March 28, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported