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Protein
Submitted name:

Fibroblast growth factor receptor substrate 2

Gene

FRS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Fibroblast growth factor receptor substrate 2Imported
Submitted name:
Fibroblast growth factor receptor substrate 2, isoform CRA_aImported
Gene namesi
Name:FRS2Imported
ORF Names:hCG_23661Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSG00000166225.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299293.

Structurei

3D structure databases

SMRiL7RTG7. Positions 11-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 115103IRS-type PTBInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
KOiK12461.
OMAiTRRRDCT.
OrthoDBiEOG091G06AV.
PhylomeDBiL7RTG7.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

L7RTG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCCSCPDK DTVPDNHRNK FKVINVDDDG NELGSGIMEL TDTELILYTR
60 70 80 90 100
KRDSVKWHYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CARAEELFNM
110 120 130 140 150
LQEIMQNNSI NVVEEPVVER NNHQTELEVP RTPRTPTTPG FAAQNLPNGY
160 170 180 190 200
PRYPSFGDAS SHPSSRHPSV GSARLPSVGE ESTHPLLVAE EQVHTYVNTT
210 220 230 240 250
GVQEERKNRT SVHVPLEARV SNAESSTPKE EPSSIEDRDP QILLEPEGVK
260 270 280 290 300
FVLGPTPVQK QLMEKEKLEQ LGRDQVSGSG ANNTEWDTGY DSDERRDAPS
310 320 330 340 350
VNKLVYENIN GLSIPSASGV RRGRLTSTST SDTQNINNSA QRRTALLNYE
360 370 380 390 400
NLPSLPPVWE ARKLSRDEDD NLGPKTPSLN GYHNNLDPMH NYVNTENVTV
410 420 430 440 450
PASAHKIEYS RRRDCTPTVF NFDIRRPSLE HRQLNYIQVD LEGGSDSDNP
460 470 480 490 500
QTPKTPTTPL PQTPTRRTEL YAVIDIERTA AMSNLQKALP RDDGTSRKTR

HNSTDLPM
Length:508
Mass (Da):57,029
Last modified:April 3, 2013 - v1
Checksum:i833714EE12097C75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX512443 Genomic DNA. Translation: AGC09590.1.
CH471054 Genomic DNA. Translation: EAW97226.1.
RefSeqiNP_001036020.1. NM_001042555.2.
NP_001265280.1. NM_001278351.1.
NP_001265282.1. NM_001278353.1.
NP_001265283.1. NM_001278354.1.
NP_001265284.1. NM_001278355.1.
NP_001265285.1. NM_001278356.1.
NP_001265286.1. NM_001278357.1.
NP_006645.3. NM_006654.4.
UniGeneiHs.593446.

Genome annotation databases

GeneIDi10818.
KEGGihsa:10818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX512443 Genomic DNA. Translation: AGC09590.1.
CH471054 Genomic DNA. Translation: EAW97226.1.
RefSeqiNP_001036020.1. NM_001042555.2.
NP_001265280.1. NM_001278351.1.
NP_001265282.1. NM_001278353.1.
NP_001265283.1. NM_001278354.1.
NP_001265284.1. NM_001278355.1.
NP_001265285.1. NM_001278356.1.
NP_001265286.1. NM_001278357.1.
NP_006645.3. NM_006654.4.
UniGeneiHs.593446.

3D structure databases

SMRiL7RTG7. Positions 11-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000299293.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10818.
KEGGihsa:10818.

Organism-specific databases

CTDi10818.

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
KOiK12461.
OMAiTRRRDCT.
OrthoDBiEOG091G06AV.
PhylomeDBiL7RTG7.

Miscellaneous databases

ChiTaRSiFRS2. human.
GenomeRNAii10818.

Gene expression databases

BgeeiENSG00000166225.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiL7RTG7_HUMAN
AccessioniPrimary (citable) accession number: L7RTG7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: September 7, 2016
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.