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Protein

Integrin beta

Gene

ITGB5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported
Biological processCell adhesionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:ITGB5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000082781.11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei720 – 742HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501109625425 – 799Integrin betaSequence analysisAdd BLAST775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 46UniRule annotation
Disulfide bondi39 ↔ 75UniRule annotation
Disulfide bondi49 ↔ 64UniRule annotation
Disulfide bondi202 ↔ 211UniRule annotation
Disulfide bondi259 ↔ 300UniRule annotation
Disulfide bondi401 ↔ 413UniRule annotation
Disulfide bondi433 ↔ 682UniRule annotation
Disulfide bondi461 ↔ 465UniRule annotation
Disulfide bondi484 ↔ 522UniRule annotation
Disulfide bondi489 ↔ 498UniRule annotation
Disulfide bondi500 ↔ 513UniRule annotation
Disulfide bondi528 ↔ 533UniRule annotation
Disulfide bondi530 ↔ 563UniRule annotation
Disulfide bondi535 ↔ 548UniRule annotation
Disulfide bondi550 ↔ 555UniRule annotation
Disulfide bondi569 ↔ 574UniRule annotation
Disulfide bondi571 ↔ 602UniRule annotation
Disulfide bondi576 ↔ 585UniRule annotation
Disulfide bondi608 ↔ 613UniRule annotation
Disulfide bondi610 ↔ 657UniRule annotation
Disulfide bondi615 ↔ 625UniRule annotation
Disulfide bondi628 ↔ 631UniRule annotation
Disulfide bondi635 ↔ 644UniRule annotation
Disulfide bondi641 ↔ 714UniRule annotation
Disulfide bondi661 ↔ 690UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDbiL7RT22.

Expressioni

Gene expression databases

BgeeiENSG00000082781.

Interactioni

Protein-protein interaction databases

IntActiL7RT22. 6 interactors.

Structurei

3D structure databases

SMRiL7RT22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 76PSIInterPro annotationAdd BLAST50
Domaini35 – 463INBInterPro annotationAdd BLAST429
Domaini137 – 372VWFAInterPro annotationAdd BLAST236
Domaini635 – 719Integrin_B_tailInterPro annotationAdd BLAST85
Domaini743 – 790Integrin_b_cytInterPro annotationAdd BLAST48

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
KOiK06588.
OMAiPDACSTK.
OrthoDBiEOG091G029W.

Family and domain databases

Gene3Di1.20.5.100. 1 hit.
1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR021157. Cyt_c1_TM_anchor_C.
IPR027067. Integrin_beta-5.
IPR033760. Integrin_beta_N.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR037076. Integrin_bsu_cyt_dom_sf.
IPR012896. Integrin_bsu_tail.
IPR036349. Integrin_bsu_tail_dom_sf.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom_sf.
IPR016201. PSI.
IPR002035. VWF_A.
IPR036465. vWFA_dom_sf.
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF26. PTHR10082:SF26. 1 hit.
PfamiView protein in Pfam
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiView protein in SMART
SM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.

Sequencei

Sequence statusi: Complete.

L7RT22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRAPAPLYA CLLGLCALLP RLAGLNICTS GSATSCEECL LIHPKCAWCS
60 70 80 90 100
KEDFGSPRSI TSRCDLRANL VKNGCGGEIE SPASSFHVLR SLPLSSKGSG
110 120 130 140 150
SAGWDVIQMT PQEIAVNLRP GDKTTFQLQV RQVEDYPVDL YYLMDLSLSM
160 170 180 190 200
KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG SFVDKDISPF SYTAPRYQTN
210 220 230 240 250
PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS RNRDAPEGGF
260 270 280 290 300
DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC
310 320 330 340 350
HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA
360 370 380 390 400
LIPGTTVEIL DGDSKNIIQL IINAYNSIRS KVELSVWDQP EDLNLFFTAT
410 420 430 440 450
CQDGVSYPGQ RKCEGLKIGD TASFEVSLEA RSCPSRHTEH VFALRPVGFR
460 470 480 490 500
DSLEVGVTYN CTCGCSVGLE PNSARCNGSG TYVCGLCECS PGYLGTRCEC
510 520 530 540 550
QDGENQSVYQ NLCREAEGKP LCSGRGDCSC NQCSCFESEF GKIYGPFCEC
560 570 580 590 600
DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD ISTCRGRDGQ
610 620 630 640 650
ICSERGHCLC GQCQCTEPGA FGEMCEKCPT CPDACSTKRD CVECLLLHSG
660 670 680 690 700
KPDNQTCHSL CRDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFTYVELP
710 720 730 740 750
SGKSNLTVLR EPECGNTPNA MTILLAVVGS ILLVGLALLA IWKLLVTIHD
760 770 780 790
RREFAKFQSE RSRARYEMAS NPLYRKPIST HTVDFTFNKF NKSYNGTVD
Length:799
Mass (Da):88,054
Last modified:April 3, 2013 - v1
Checksum:iD7E4727CA310512B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM005630 mRNA. Translation: AEE61227.1.
JX512446 Genomic DNA. Translation: AGC09593.1.
RefSeqiNP_002204.2. NM_002213.4.
UniGeneiHs.13155.
Hs.536663.

Genome annotation databases

GeneIDi3693.
KEGGihsa:3693.

Similar proteinsi

Entry informationi

Entry nameiL7RT22_HUMAN
AccessioniPrimary (citable) accession number: L7RT22
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: November 22, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.