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L7IP31 (ERG6_MAGOY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 7. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sterol 24-C-methyltransferase

EC=2.1.1.41
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene names
Name:ERG6
ORF Names:OOU_Y34scaffold00069g5
OrganismMagnaporthe oryzae (strain Y34) (Rice blast fungus) (Pyricularia oryzae) [Complete proteome]
Taxonomic identifier1143189 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.

Catalytic activity

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathway

Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Sterol 24-C-methyltransferase
PRO_0000423543

Experimental info

Sequence conflict2461D → N in AAX07631. Ref.1

Sequences

Sequence LengthMass (Da)Tools
L7IP31 [UniParc].

Last modified March 6, 2013. Version 1.
Checksum: 4442B9609B8DA9D5

FASTA39043,036
        10         20         30         40         50         60 
MSKQQHPSSK TQITRRRDTA DMTFEQVLHK GSSANMGGLS SMLGKDREAS KTAVDQYFRH 

        70         80         90        100        110        120 
WDGKTAKTET TKVREERKAD YATLTRQYYN LVTDFYEYGW GQSFHFCTFA PGETFASAIT 

       130        140        150        160        170        180 
RYEHTLAHRI GIKKGMKVLD IGCGVGGPAR QIAKFTGANI TGITINEYQV ERARRYAEME 

       190        200        210        220        230        240 
GYGAGEQLKF VQGDFMALPF EKETFDAVYS IEATVHAPKL EDVYKQIFNV LKPGGIFGLY 

       250        260        270        280        290        300 
EWVMTDAYDE NDPHHKEIRF GIEHGGGIAN LQTAQTAIAA IKAAGFELLE SEDLADNSDR 

       310        320        330        340        350        360 
APWYWPLGGN AWQYASTFGD ILSTFTMTPA GRAIAHTVLG VVESIGLVPP GTKKTADSLS 

       370        380        390 
TTAAALVAGG KEGLFTPMFL MVARKPVAKE 

« Hide

References

« Hide 'large scale' references
[1]Dong H.T., Peng Y.L., Chen B.S., Li Y.Z., Li D.B.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Y34.
Tissue: Conidium.
[2]"Comparative analysis of the genomes of two field isolates of the rice blast fungus Magnaporthe oryzae."
Xue M., Yang J., Li Z., Hu S., Yao N., Dean R.A., Zhao W., Shen M., Zhang H., Li C., Liu L., Cao L., Xu X., Xing Y., Hsiang T., Zhang Z., Xu J.-R., Peng Y.-L.
PLoS Genet. 8:E1002869-E1002869(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y34.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY849610 mRNA. Translation: AAX07631.1.
JH793273 Genomic DNA. Translation: ELQ44666.1.

3D structure databases

ProteinModelPortalL7IP31.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiMGG_04346T0; MGG_04346T0; MGG_04346.

Enzyme and pathway databases

UniPathwayUPA00768; UER00760.

Family and domain databases

Gene3D3.40.50.150. 2 hits.
InterProIPR025810. ERG6.
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamPF13847. Methyltransf_31. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 2 hits.
PROSITEPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERG6_MAGOY
AccessionPrimary (citable) accession number: L7IP31
Secondary accession number(s): A4R5U1, G4NGD4, Q5EN22
Entry history
Integrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: March 6, 2013
Last modified: June 11, 2014
This is version 7 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways