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L7IP31

- ERG6_MAGOY

UniProt

L7IP31 - ERG6_MAGOY

Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Magnaporthe oryzae (strain Y34) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 8 (01 Oct 2014)
      Sequence version 1 (06 Mar 2013)
      Previous versions | rss
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    Functioni

    Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

    Pathwayi

    GO - Molecular functioni

    1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sterol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00768; UER00760.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol 24-C-methyltransferase (EC:2.1.1.41)
    Alternative name(s):
    Delta(24)-sterol C-methyltransferase
    Gene namesi
    Name:ERG6
    ORF Names:OOU_Y34scaffold00069g5
    OrganismiMagnaporthe oryzae (strain Y34) (Rice blast fungus) (Pyricularia oryzae)
    Taxonomic identifieri1143189 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
    ProteomesiUP000011086: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Sterol 24-C-methyltransferasePRO_0000423543Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliL7IP31.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.40.50.150. 2 hits.
    InterProiIPR025810. ERG6.
    IPR025714. Methyltranfer_dom.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view]
    PfamiPF13847. Methyltransf_31. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    L7IP31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKQQHPSSK TQITRRRDTA DMTFEQVLHK GSSANMGGLS SMLGKDREAS    50
    KTAVDQYFRH WDGKTAKTET TKVREERKAD YATLTRQYYN LVTDFYEYGW 100
    GQSFHFCTFA PGETFASAIT RYEHTLAHRI GIKKGMKVLD IGCGVGGPAR 150
    QIAKFTGANI TGITINEYQV ERARRYAEME GYGAGEQLKF VQGDFMALPF 200
    EKETFDAVYS IEATVHAPKL EDVYKQIFNV LKPGGIFGLY EWVMTDAYDE 250
    NDPHHKEIRF GIEHGGGIAN LQTAQTAIAA IKAAGFELLE SEDLADNSDR 300
    APWYWPLGGN AWQYASTFGD ILSTFTMTPA GRAIAHTVLG VVESIGLVPP 350
    GTKKTADSLS TTAAALVAGG KEGLFTPMFL MVARKPVAKE 390
    Length:390
    Mass (Da):43,036
    Last modified:March 6, 2013 - v1
    Checksum:i4442B9609B8DA9D5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti246 – 2461D → N in AAX07631. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY849610 mRNA. Translation: AAX07631.1.
    JH793273 Genomic DNA. Translation: ELQ44666.1.

    Genome annotation databases

    EnsemblFungiiMGG_04346T0; MGG_04346T0; MGG_04346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY849610 mRNA. Translation: AAX07631.1 .
    JH793273 Genomic DNA. Translation: ELQ44666.1 .

    3D structure databases

    ProteinModelPortali L7IP31.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii MGG_04346T0 ; MGG_04346T0 ; MGG_04346 .

    Enzyme and pathway databases

    UniPathwayi UPA00768 ; UER00760 .

    Family and domain databases

    Gene3Di 3.40.50.150. 2 hits.
    InterProi IPR025810. ERG6.
    IPR025714. Methyltranfer_dom.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view ]
    Pfami PF13847. Methyltransf_31. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Dong H.T., Peng Y.L., Chen B.S., Li Y.Z., Li D.B.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Y34.
      Tissue: Conidium.
    2. "Comparative analysis of the genomes of two field isolates of the rice blast fungus Magnaporthe oryzae."
      Xue M., Yang J., Li Z., Hu S., Yao N., Dean R.A., Zhao W., Shen M., Zhang H., Li C., Liu L., Cao L., Xu X., Xing Y., Hsiang T., Zhang Z., Xu J.-R., Peng Y.-L.
      PLoS Genet. 8:E1002869-E1002869(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y34.

    Entry informationi

    Entry nameiERG6_MAGOY
    AccessioniPrimary (citable) accession number: L7IP31
    Secondary accession number(s): A4R5U1, G4NGD4, Q5EN22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 18, 2013
    Last sequence update: March 6, 2013
    Last modified: October 1, 2014
    This is version 8 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3