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Protein

Annexin

Gene

PAL_GLEAN10021096

Organism
Pteropus alecto (Black flying fox)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

LigandCalcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
ORF Names:PAL_GLEAN10021096Imported
OrganismiPteropus alecto (Black flying fox)Imported
Taxonomic identifieri9402 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMegachiropteraPteropodidaePteropodinaePteropus
Proteomesi
  • UP000010552 Componenti: Unassembled WGS sequence

Family & Domainsi

Domaini

The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

InParanoidiL5K6B2.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiView protein in InterPro
IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR037104. Annexin_sf.
IPR002388. ANX1.
PANTHERiPTHR10502:SF17. PTHR10502:SF17. 1 hit.
PfamiView protein in Pfam
PF00191. Annexin. 4 hits.
PRINTSiPR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTiView protein in SMART
SM00335. ANX. 4 hits.
PROSITEiView protein in PROSITE
PS00223. ANNEXIN. 3 hits.

Sequencei

Sequence statusi: Complete.

L5K6B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFQELCVPN MEIMMEAGAC ETSSKMSMVS EFLKQAWFIE NEEQEYVKTV
60 70 80 90 100
KASKGGPGSA VSPYPSFNPS SDVDALHKAI MVKGVDEATI IDILTKRNNA
110 120 130 140 150
QRQQIKAAYL QEKGKPLDEV LKKALTGHLE EVALALLKTP ARFDADELRA
160 170 180 190 200
AMKGLGTDEE TLDEILASRT NREIREINRV YREELKRDLA KDITSDTSGD
210 220 230 240 250
YQKALLSLAK GDRSEDIGIN EDLADSDARA LYEAGERRKG TDVNVFTTIL
260 270 280 290 300
TTRSYPHLRR VFQKYTKYSQ HDMNKVLDLE MKGDIEKCFT TIVKCATNKP
310 320 330 340 350
MFFAEKLHQA MKGAGTRHKA LIRIMVSRSE IDMNDIKACY QKLYGISLCQ
360 370
AILDETKGDY EKILVALCGG Q
Length:371
Mass (Da):41,648
Last modified:March 6, 2013 - v1
Checksum:iCE24E9808892EE98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB030986 Genomic DNA. Translation: ELK07065.1.

Similar proteinsi

Entry informationi

Entry nameiL5K6B2_PTEAL
AccessioniPrimary (citable) accession number: L5K6B2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: October 25, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported