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Protein

Protein argonaute-3

Gene

EIF2C3

Organism
Pteropus alecto (Black flying fox)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoproteinUniRule annotation, RNA-bindingUniRule annotation
Biological processRNA-mediated gene silencingUniRule annotationSAAS annotation, Translation regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein argonaute-3UniRule annotation
Short name:
Argonaute3UniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 2C 3UniRule annotation
Short name:
eIF-2C 3UniRule annotation
Short name:
eIF2C 3UniRule annotation
Gene namesi
Name:EIF2C3UniRule annotation
Synonyms:AGO3UniRule annotation
ORF Names:PAL_GLEAN10014958Imported
OrganismiPteropus alecto (Black flying fox)Imported
Taxonomic identifieri9402 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMegachiropteraPteropodidaePteropodinaePteropus
Proteomesi
  • UP000010552 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini358 – 471PAZInterPro annotationAdd BLAST114
Domaini640 – 941PiwiInterPro annotationAdd BLAST302

Sequence similaritiesi

Belongs to the argonaute family. Ago subfamily.UniRule annotation

Phylogenomic databases

InParanoidiL5JUK4.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_03032. AGO3. 1 hit.
InterProiView protein in InterPro
IPR028603. AGO3.
IPR014811. ArgoL1.
IPR032472. ArgoL2.
IPR032473. Argonaute_Mid_dom.
IPR032474. Argonaute_N.
IPR003100. PAZ_dom.
IPR036085. PAZ_dom_sf.
IPR003165. Piwi.
IPR012337. RNaseH-like_sf.
IPR036397. RNaseH_sf.
PfamiView protein in Pfam
PF08699. ArgoL1. 1 hit.
PF16488. ArgoL2. 1 hit.
PF16487. ArgoMid. 1 hit.
PF16486. ArgoN. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
SMARTiView protein in SMART
SM01163. DUF1785. 1 hit.
SM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiView protein in PROSITE
PS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.

Sequencei

Sequence statusi: Complete.

L5JUK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIGSAGECG RASGSVCGGV SRASSLPQPA SGREVNAVRA APPLRPPPGP
60 70 80 90 100
SSAFPQPRRS SPEPLSRRNW GERKVLKFGV LSATFFFSWR LEGFAFVFVI
110 120 130 140 150
PVGEVTVEAA VIFLEIEKLR NLFLFGQNGP VGAQPLLMVP RRPGYGSMGK
160 170 180 190 200
PIKLLANCFQ VEIPKIDVYL YEVDIKPDKC PRRVNREVVD SMVQHFKVTI
210 220 230 240 250
FGDCRPVYDG KRSLYTANPL PVATTGVDLD VTLPGEGGKD RPFKVSIKFV
260 270 280 290 300
SRVSWHLLHE VLTGRTLPEP LELDKPISTN PVHAVDVVLR HLPSMKYTPV
310 320 330 340 350
GRSFFSAPEG YDHPLGGGRE VWFGFHQSVR PAMWKMMLNI DVSATAFYKA
360 370 380 390 400
QPVIQFMCEV LDIHNIDEQP RPLTDSHRVK FTKEIKGLKV EVTHCGTMRR
410 420 430 440 450
KYRVCNVTRR PASHQTFPLQ LENGQTVERT VAQYFREKYT LQLKYPHLPC
460 470 480 490 500
LQVGQEQKHT YLPLEVCNIV AGQRCIKKLT DNQTSTMIKA TARSAPDRQE
510 520 530 540 550
EISRLVRSAN YETDPFVQEF QFKVRDEMAH VTGRVLPAPM LQYGGRNRTV
560 570 580 590 600
ATPSHGVWDM RGKQFHTGVE IKMWAIACFA TQRQCREEIL KGFTDQLRKI
610 620 630 640 650
SKDAGMPIQG QPCFCKYAQG ADSVEPMFRH LKNTYSGLQL IIVILPGKTP
660 670 680 690 700
VYAEVKRVGD TLLGMATQCV QVKNVIKTSP QTLSNLCLKI NVKLGGINNI
710 720 730 740 750
LVPHQRPSVF QQPVIFLGAD VTHPPAGDGK KPSIAAVVGS MDAHPSRYCA
760 770 780 790 800
TVRVQRPRQE IIQDLASMVR ELLIQFYKST RFKPTRIIFY RDGVSEGQFR
810 820 830 840 850
QVLYYELLAI REACISLEKD YQPGITYIVV QKRHHTRLFC ADRTERVGRS
860 870 880 890 900
GNIPAGTTVD TDITHPYEFD FYLCSHAGIQ GTSRPSHYHV LWDDNCFNAD
910 920 930 940 950
ELQLLTYQLC HTYVRCTRSV SIPAPAYYAH LVAFRARYHL VDKEHDSAEG
960 970 980
SHVSGQSNGR DPQALAKAVQ IHQDTLRTMY FA
Length:982
Mass (Da):110,517
Last modified:March 6, 2013 - v1
Checksum:i10EEE4C6E96586E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB031148 Genomic DNA. Translation: ELK01973.1.

Similar proteinsi

Entry informationi

Entry nameiL5JUK4_PTEAL
AccessioniPrimary (citable) accession number: L5JUK4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: October 25, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported