ID   H2LPW5_ORYLA            Unreviewed;       467 AA.
AC   H2LPW5; L0N7M7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=neu4 {ECO:0000313|EMBL:BAM74165.1,
GN   ECO:0000313|Ensembl:ENSORLP00000008101.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008101.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000008101.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008101.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|EMBL:BAM74165.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Hd-rR {ECO:0000313|EMBL:BAM74165.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:BAM74165.1};
RA   Shiozaki K., Matushita N., Takeshita K., Ryuzono S.;
RT   "Molecular cloning of medaka neu4.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSORLP00000008101.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008101.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC         (2->8)- glycosidic linkages of terminal sialic acid residues in
CC         oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC         synthetic substrates.; EC=3.2.1.18;
CC         Evidence={ECO:0000256|ARBA:ARBA00000427};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; AB774292; BAM74165.1; -; mRNA.
DR   RefSeq; NP_001274477.1; NM_001287548.1.
DR   RefSeq; XP_011480494.1; XM_011482192.1.
DR   STRING; 8090.ENSORLP00000008101; -.
DR   Ensembl; ENSORLT00000008102.2; ENSORLP00000008101.2; ENSORLG00000006455.2.
DR   GeneID; 101160183; -.
DR   KEGG; ola:101160183; -.
DR   CTD; 129807; -.
DR   eggNOG; ENOG502QSFT; Eukaryota.
DR   GeneTree; ENSGT00950000182944; -.
DR   HOGENOM; CLU_024620_2_1_1; -.
DR   OrthoDB; 5482010at2759; -.
DR   TreeFam; TF331063; -.
DR   BRENDA; 3.2.1.18; 3199.
DR   Proteomes; UP000001038; Chromosome 13.
DR   Bgee; ENSORLG00000006455; Expressed in sexually immature organism and 1 other cell type or tissue.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IBA:GO_Central.
DR   GO; GO:0006689; P:ganglioside catabolic process; IBA:GO_Central.
DR   GO; GO:0009313; P:oligosaccharide catabolic process; IBA:GO_Central.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF22; SIALIDASE-4; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   2: Evidence at transcript level;
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT   DOMAIN          63..372
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          428..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   467 AA;  52288 MW;  6DE5C487EEA30F0D CRC64;
     MRSPYFPARS VLFRKESNGV TYRVPALIYV PRNRTFLAFC EERLSPSDSQ AHLLVVRKGT
     FYRNYVEWGN ISVLGTAYLP GHRSMNPCPV FDDFTGTLFL FFIAVLGHTS ESYQLVTGKN
     VTRLCYISST DGGDTWSPVT DLTKTVIGDT IKDWATFALG PGHGLQLKSG RLLIPAYAYH
     IECKECLGRL CQTTPRSFCF HSDTHGRSWR FGEAIPAPES VECQMVSVDE EDGSNVLYCN
     ARSPLGYRVQ ALSLDDGAVF QSGQLVPRLV EPRNGCHGSI VGFPAPLHLS KSLKNCSKRL
     VSRHWTSHTS NMHLHHPNPD FLNPTWVVYS HPTLTTARQD LGLFLSLFPR DPDSWRGPWV
     IYEGPSAYSD LAYLELSASP GAVPAVAFAC LFECGTKTPY DEICFSIFTL YELIDNLPVD
     VQPREDDCRQ TSGSCKQQTQ RTPAVQPRPH VKKRRKKSKL LEMCSSS
//