ID L0M0K5_ENTBF Unreviewed; 440 AA. AC L0M0K5; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 27-MAR-2024, entry version 67. DE RecName: Full=Xylose isomerase {ECO:0000256|ARBA:ARBA00011958, ECO:0000256|HAMAP-Rule:MF_00455}; DE EC=5.3.1.5 {ECO:0000256|ARBA:ARBA00011958, ECO:0000256|HAMAP-Rule:MF_00455}; GN Name=xylA {ECO:0000256|HAMAP-Rule:MF_00455}; GN OrderedLocusNames=D782_0162 {ECO:0000313|EMBL:AGB76241.1}; OS Enterobacteriaceae bacterium (strain FGI 57). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae. OX NCBI_TaxID=693444 {ECO:0000313|EMBL:AGB76241.1, ECO:0000313|Proteomes:UP000011002}; RN [1] {ECO:0000313|EMBL:AGB76241.1, ECO:0000313|Proteomes:UP000011002} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FGI 57 {ECO:0000313|EMBL:AGB76241.1, RC ECO:0000313|Proteomes:UP000011002}; RX PubMed=23469353; DOI=10.1128/genomeA.00238-12; RA Aylward F.O., Tremmel D.M., Bruce D.C., Chain P., Chen A., RA Walston Davenport K., Detter C., Han C.S., Han J., Huntemann M., RA Ivanova N.N., Kyrpides N.C., Markowitz V., Mavrommatis K., Nolan M., RA Pagani I., Pati A., Pitluck S., Deshpande S., Goodwin L., Woyke T., RA Currie C.R.; RT "Complete genome of Enterobacteriaceae bacterium strain FGI 57, a strain RT associated with leaf-cutter ant fungus gardens."; RL Genome Announc. 1:E00238-12(2013). CC -!- CATALYTIC ACTIVITY: CC Reaction=alpha-D-xylose = alpha-D-xylulofuranose; Xref=Rhea:RHEA:22816, CC ChEBI:CHEBI:28518, ChEBI:CHEBI:188998; EC=5.3.1.5; CC Evidence={ECO:0000256|ARBA:ARBA00033659, ECO:0000256|HAMAP- CC Rule:MF_00455, ECO:0000256|RuleBase:RU000609}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP- CC Rule:MF_00455}; CC Note=Binds 2 magnesium ions per subunit. {ECO:0000256|HAMAP- CC Rule:MF_00455}; CC -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00455, CC ECO:0000256|RuleBase:RU000610}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00455, CC ECO:0000256|RuleBase:RU000610}. CC -!- SIMILARITY: Belongs to the xylose isomerase family. CC {ECO:0000256|ARBA:ARBA00005765, ECO:0000256|HAMAP-Rule:MF_00455, CC ECO:0000256|RuleBase:RU000609}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP003938; AGB76241.1; -; Genomic_DNA. DR AlphaFoldDB; L0M0K5; -. DR STRING; 693444.D782_0162; -. DR KEGG; ebf:D782_0162; -. DR PATRIC; fig|693444.3.peg.160; -. DR eggNOG; COG2115; Bacteria. DR HOGENOM; CLU_037261_1_0_6; -. DR OrthoDB; 9763981at2; -. DR Proteomes; UP000011002; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0009045; F:xylose isomerase activity; IEA:UniProtKB-UniRule. DR GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-UniRule. DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1. DR HAMAP; MF_00455; Xylose_isom_A; 1. DR InterPro; IPR036237; Xyl_isomerase-like_sf. DR InterPro; IPR013452; Xylose_isom_bac. DR InterPro; IPR001998; Xylose_isomerase. DR NCBIfam; TIGR02630; xylose_isom_A; 1. DR PANTHER; PTHR48320; -; 1. DR PANTHER; PTHR48320:SF1; XYLOSE ISOMERASE; 1. DR PRINTS; PR00688; XYLOSISMRASE. DR SUPFAM; SSF51658; Xylose isomerase-like; 1. DR PROSITE; PS51415; XYLOSE_ISOMERASE; 1. PE 3: Inferred from homology; KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP- KW Rule:MF_00455}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00455}; KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_00455}; KW Magnesium {ECO:0000256|HAMAP-Rule:MF_00455}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP- KW Rule:MF_00455}; Reference proteome {ECO:0000313|Proteomes:UP000011002}; KW Xylose metabolism {ECO:0000256|ARBA:ARBA00022629, ECO:0000256|HAMAP- KW Rule:MF_00455}. FT ACT_SITE 101 FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT ACT_SITE 104 FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 232 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 268 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 268 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 271 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 296 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 307 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 309 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="2" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" FT BINDING 339 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_label="1" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00455" SQ SEQUENCE 440 AA; 49814 MW; F18CB60011801231 CRC64; MQAYFDQLDR VRFEGPKTEN PLAFRHYNPD ELVLGKRMED HLRFAACYWH TFCWNGADMF GVGAFDRPWQ QPGEAIALAK RKADVAFEFF HKLNVPYYCF HDVDVSPEGA SLKEYLNNFA QMVDVLAEKQ QQSGVKLLWG TANCFTNPRY GAGAATNPDP EVFSWAATQV FTAMNATHKL GGENYVLWGG REGYESLLNT DLRQEREQIG RFMQMVVEHK HKIGFQGTLL IEPKPQEPTK HQYDYDASTV YGFLKQFGLE KEIKLNIEAN HATLAGHSFH HEIATAIALG LFGSVDANRG DPQLGWDTDQ FPNSVEENAL VMYEILKAGG FTTGGLNFDA KVRRQSTDKY DLFYGHIGAM DTMALSLKVA ARMIEGGELD KRVAKRYAGW NGELGQQILK GQMSLQDLAK YAEQHQLAPQ HQSGHQELLE NLVNHYLFDK //