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Protein

Putrescine aminotransferase

Gene

patA

Organism
Enterobacteriaceae bacterium (strain FGI 57)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine.UniRule annotation

Catalytic activityi

Putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: putrescine degradation

This protein is involved in step 1 of the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Putrescine aminotransferase (patA)
This subpathway is part of the pathway putrescine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route), the pathway putrescine degradation and in Amine and polyamine degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00188; UER00290.

Names & Taxonomyi

Protein namesi
Recommended name:
Putrescine aminotransferaseUniRule annotation (EC:2.6.1.82UniRule annotation)
Alternative name(s):
Putrescine--2-oxoglutaric acid transaminaseUniRule annotation
Short name:
PATUniRule annotation
Short name:
PATaseUniRule annotation
Gene namesi
Name:patAUniRule annotation
Ordered Locus Names:D782_0607Imported
OrganismiEnterobacteriaceae bacterium (strain FGI 57)Imported
Taxonomic identifieri693444 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceae
Proteomesi
  • UP000011002 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei339N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliL0LYE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.UniRule annotation

Phylogenomic databases

KOiK09251.
OMAiLIHGQYT.
OrthoDBiPOG091H0A4W.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01276. Putres_aminotrans_3. 1 hit.
InterProiView protein in InterPro
IPR005814. Aminotrans_3.
IPR017747. Putrescine_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03372. putres_am_tran. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

L0LYE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLHFSLVFI PIFSARVEVA QSLQYLIQYR VIRDPRELIL NRLPSSASAL
60 70 80 90 100
ACSAHALNLI EKRTLDHEEM KALNQEVREY FKEHVNPGFL EYRKSVTAGG
110 120 130 140 150
DYGAVEWQAG SLNTLVDTQG QEFIDCLGGF GIFNVGHRNP VVVSAVQNQL
160 170 180 190 200
VKQPLHSQEL LDPLRAMLAK TLAALAPGKL KYSFFSNSGT ESVEAALKLA
210 220 230 240 250
KAYQSPRGKF TFIATSGAFH GKSLGALSAT AKSTFRKPFM PLLPGFRHVP
260 270 280 290 300
FGNIDAMRLA LSECQKTGDD VAAVILEPIQ GEGGVILPPQ GYLPAVRKLC
310 320 330 340 350
DEFGALLIFD EVQTGMGRTG KMFACEHENV QPDILCLAKA LGGGVMPIGA
360 370 380 390 400
TIATEEVFSV LFDNPFLHTT TFGGNPLACA AALATINVLL TENLPAQAEQ
410 420 430 440 450
KGDMLLDGFR SLAREYPDLV REARGKGMLM AIEFVDNEIG YSFASEMFRQ
460 470 480 490 500
RVLVAGTLNN AKTIRIEPPL TLTIEQCELV LKATRKALAS LRVEKQVTTE

Q
Length:501
Mass (Da):54,716
Last modified:March 6, 2013 - v1
Checksum:iCE9B0775224748F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003938 Genomic DNA. Translation: AGB76663.1.

Genome annotation databases

EnsemblBacteriaiAGB76663; AGB76663; D782_0607.
KEGGiebf:D782_0607.
PATRICifig|693444.3.peg.590.

Similar proteinsi

Entry informationi

Entry nameiL0LYE8_ENTBF
AccessioniPrimary (citable) accession number: L0LYE8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: September 27, 2017
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported