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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium smegmatis JS623
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei161 – 1611UniRule annotation
Active sitei593 – 5931UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
ORF Names:Mycsm_02866Imported
OrganismiMycobacterium smegmatis JS623Imported
Taxonomic identifieri710686 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000010844 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

L0IXX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGPDVALA PIGSVRRTQV GREATEPMRE DIRLLGTILG DTVREQNGEE
60 70 80 90 100
VFDLVERARV ESFRVRRSEI DRAELARMFD GIDIHQAIPV IRAFSHFALL
110 120 130 140 150
ANVAEDIHRE RRRAVHVAAG EPPQNSSLAA TYLKLDSAEL DSATVADALR
160 170 180 190 200
GALVAPVITA HPTETRRRTV FDTQHRITEL MRLRLHGQTE TDDGRNINLE
210 220 230 240 250
LRRHIFTLWQ TALIRLSRLK IQDEIKTGLR YYQAAFLEVI PKVNAEVRTA
260 270 280 290 300
LQARWPEADL LELPILRPGS WIGGDRDGNP NVTADVVRQA TGRASYTAFE
310 320 330 340 350
HYFTEISALE QELSMSARLV KVSDDLAALA DKCHEPARAD EPYRRALRVI
360 370 380 390 400
HGRLTATAGE ILDSQPEHEL DLGLQRYVTP AELLADLDVI DHSLRSNGSG
410 420 430 440 450
VLADDRLAQL REAVRVFGFH LSGLDLRQNS DVHEEVVAEL LAWAGVHADY
460 470 480 490 500
QSLSEPERVE LLAAELATRR PLTKDDAELS ELARKELDIV AAAARAVHVY
510 520 530 540 550
GPHAIPNYII SMCQSVSDML EAAILLKEVG LLDASGDEPY APVGIVPLFE
560 570 580 590 600
TIDDLQRGSS ILEAVLDLPL YRAVVTARGD SQEVMLGYSD SNKDGGYLAA
610 620 630 640 650
NWALYRAELD LVESARKTGI RLRLFHGRGG TVGRGGGPSY DAILAQPPGA
660 670 680 690 700
VNGSLRITEQ GEVIAAKYAE PRVAHRNLET LLAATLEATL LDVEGLGDAA
710 720 730 740 750
EPAYEVLDEL AARAQRAYAE LVHVTPGFVE YFKASTPVSE IGALNIGSRP
760 770 780 790 800
TSRKPTTSIS DLRAIPWVLA WSQSRVMLPG WYGTGAAFEG WIAEGDGRLE
810 820 830 840 850
VLQDLYHRWP FFRTVLSNMA QVLSKSDMGL AARYSELVED EALRQRVFDK
860 870 880 890 900
IVDEHDRTIR MHKLITGQDD LLADNPALAR SVFNRFPYLE PLNHLQVELL
910 920 930
RRYRSGDDDE LVQRGILLTM SGLATALRNS G
Length:931
Mass (Da):103,045
Last modified:March 6, 2013 - v1
Checksum:i46ADB222FDF7717E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003078 Genomic DNA. Translation: AGB23192.1.
RefSeqiWP_015306771.1. NC_019966.1.

Genome annotation databases

EnsemblBacteriaiAGB23192; AGB23192; Mycsm_02866.
KEGGimsa:Mycsm_02866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003078 Genomic DNA. Translation: AGB23192.1.
RefSeqiWP_015306771.1. NC_019966.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAGB23192; AGB23192; Mycsm_02866.
KEGGimsa:Mycsm_02866.

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Mycobacterium smegmatis JS623."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T., Holmes A.
    , Rutledge P., Paulsen I., Coleman N., Woyke T.
    Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JS623Imported.

Entry informationi

Entry nameiL0IXX6_MYCSM
AccessioniPrimary (citable) accession number: L0IXX6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: July 22, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.