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L0HPH2

- L0HPH2_ACIS0

UniProt

L0HPH2 - L0HPH2_ACIS0

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Protein
Ribulose bisphosphate carboxylase
Gene
rbcL, AciM339_1392
Organism
Aciduliprofundum sp. (strain MAR08-339)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei149 – 1491Proton acceptor By similarityUniRule annotation
Binding sitei151 – 1511Substrate By similarityUniRule annotation
Metal bindingi175 – 1751Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi177 – 1771Magnesium By similarityUniRule annotation
Metal bindingi178 – 1781Magnesium By similarityUniRule annotation
Active sitei265 – 2651Proton acceptor By similarityUniRule annotation
Binding sitei266 – 2661Substrate By similarityUniRule annotation
Binding sitei298 – 2981Substrate By similarityUniRule annotation
Sitei305 – 3051Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. ribulose-bisphosphate carboxylase activity Source: InterPro

GO - Biological processi

  1. carbon fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:AciM339_1392Imported
OrganismiAciduliprofundum sp. (strain MAR08-339)Imported
Taxonomic identifieri673860 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaAciduliprofundum
ProteomesiUP000010814: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliL0HPH2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni347 – 3493Substrate binding By similarityUniRule annotation
Regioni369 – 3724Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation

Phylogenomic databases

KOiK01601.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

L0HPH2-1 [UniParc]FASTAAdd to Basket

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MTYIELDYEP KDTDLLVWFY AEPPAGRDMK YVADRIAEES SIGTWTDLKT    50
LLPEIWEKLR ARVYEIDEER RYVKIAYSLH LFEVKNMPAI LASVAGNVFG 100
MKSVENLRVL DTRFPLELLS EYPGPKYGVQ GVREMTGVRD RPFLGTIIKP 150
KIGLPAKMHA EVAYEAWVGG LDIVKDDENL ASQDFNRFEE RLSLTLEKKD 200
LAEEETGEKK IYLVNITAPY REMIRRAELV QDAGNEFVMI DVFISGFSAV 250
QSYREEGFKM AIHAHRAMHA AITRNPRHGI TMLALAKIYR VLGVDNLHIG 300
TAVGKMEGSA AEVSAIREEI QMGNVPANDT RFQQSWGDIK PVLAVASGGL 350
HPGHVPAVVD ILGKDIVIQA GGGVHGHPEG TRKGATAMRQ ALEAKMQGIS 400
LQEYAKDHEE LRKALEKFVK 420
Length:420
Mass (Da):47,034
Last modified:March 6, 2013 - v1
Checksum:i93D0CBD4908AC61B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003168 Genomic DNA. Translation: AGB05248.1.
RefSeqiWP_015283871.1. NC_019942.1.
YP_007247414.1. NC_019942.1.

Genome annotation databases

EnsemblBacteriaiAGB05248; AGB05248; AciM339_1392.
GeneIDi14306529.
KEGGiacf:AciM339_1392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003168 Genomic DNA. Translation: AGB05248.1 .
RefSeqi WP_015283871.1. NC_019942.1.
YP_007247414.1. NC_019942.1.

3D structure databases

ProteinModelPortali L0HPH2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AGB05248 ; AGB05248 ; AciM339_1392 .
GeneIDi 14306529.
KEGGi acf:AciM339_1392.

Phylogenomic databases

KOi K01601.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Aciduliprofundum sp. MAR08-339."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Flores G., Reysenbach A.-L., Woyke T.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAR08-339.

Entry informationi

Entry nameiL0HPH2_ACIS0
AccessioniPrimary (citable) accession number: L0HPH2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: September 3, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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