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L0HEQ2

- L0HEQ2_METFS

UniProt

L0HEQ2 - L0HEQ2_METFS

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Protein

Ribulose bisphosphate carboxylase

Gene
rbcL, Metfor_2181
Organism
Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Proton acceptor By similarityUniRule annotation
Binding sitei154 – 1541Substrate By similarityUniRule annotation
Metal bindingi178 – 1781Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi180 – 1801Magnesium By similarityUniRule annotation
Metal bindingi181 – 1811Magnesium By similarityUniRule annotation
Active sitei270 – 2701Proton acceptor By similarityUniRule annotation
Binding sitei271 – 2711Substrate By similarityUniRule annotation
Binding sitei303 – 3031Substrate By similarityUniRule annotation
Sitei310 – 3101Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. ribulose-bisphosphate carboxylase activity Source: InterPro

GO - Biological processi

  1. carbon fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Metfor_2181Imported
OrganismiMethanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP)Imported
Taxonomic identifieri593750 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
ProteomesiUP000010824: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni353 – 3553Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation

Phylogenomic databases

KOiK01601.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

L0HEQ2-1 [UniParc]FASTAAdd to Basket

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MAIDWYKEFV DLKYEPAKDD LVCLFYFEPA AGVSGREAAG RIASESSTGT    50
WTTLFSMPPR MKALQATAFH IEGNVVKIAY PIELWEEGNT VQLMSGIAGN 100
IFGMKAVRNL RLIDVALPPA YLKHFQGPHF GNDGIRKMMG IQKRPLTGAV 150
PKPKIGFSAK EHADIGYETW MGGFDFVKDD ENLTSTSFNK FEDRVKYMTK 200
LRDKAEKETG EKKSAFLNIT ADVETMKKRA DLLAANGWNY CMIDVVVAGT 250
AAVMTMRDYC SDLGLAIHAH RAMHAALDRN RKHGISMQFL AKIMRLIGVS 300
QIHTGTAVGK LTGSRKESLA LANLLREKKT AAVEGMLLEQ DWGKIKSAFP 350
VSSGGLHPGL VPDVMDIYGP EMVLLVSGGI HGHPKGTRAG AKATMQAMEA 400
WQEGVSLEEK AKKAKELKEA LGKWGHYKPI 430
Length:430
Mass (Da):47,321
Last modified:March 6, 2013 - v1
Checksum:i80EBCB6EF255B07F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003167 Genomic DNA. Translation: AGB03187.1.
RefSeqiYP_007249694.1. NC_019943.1.

Genome annotation databases

EnsemblBacteriaiAGB03187; AGB03187; Metfor_2181.
GeneIDi14309573.
KEGGimfo:Metfor_2181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003167 Genomic DNA. Translation: AGB03187.1 .
RefSeqi YP_007249694.1. NC_019943.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AGB03187 ; AGB03187 ; Metfor_2181 .
GeneIDi 14309573.
KEGGi mfo:Metfor_2181.

Phylogenomic databases

KOi K01601.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 22288 / NBRC 105244 / SMSP.

Entry informationi

Entry nameiL0HEQ2_METFS
AccessioniPrimary (citable) accession number: L0HEQ2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: September 3, 2014
This is version 8 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi