ID   L0GD23_HUMAN            Unreviewed;       273 AA.
AC   L0GD23;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   03-MAY-2023, entry version 29.
DE   SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AGA84613.1};
DE   Flags: Fragment;
GN   Name=HLA-C {ECO:0000313|EMBL:AGA84613.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AGA84613.1};
RN   [1] {ECO:0000313|EMBL:AGA84613.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhu F., Wang W., He J.;
RT   "A novel HLA-C*01:02 allele was identified.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AGA84613.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23535199; DOI=10.1111/tan.12107;
RA   Tao S.D., Zhang W., Zhu F.M., He J., Lv H.J.;
RT   "A novel HLA allele, HLA-C*01:02:18, was identified by polymerase chain
RT   reaction sequence-based typing in a Chinese leukemia patient.";
RL   Tissue Antigens 82:65-66(2013).
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|RuleBase:RU004439}.
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DR   EMBL; JX915742; AGA84613.1; -; Genomic_DNA.
DR   AlphaFoldDB; L0GD23; -.
DR   SMR; L0GD23; -.
DR   ChiTaRS; HLA-C; human.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   PANTHER; PTHR16675:SF252; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          184..272
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGA84613.1"
FT   NON_TER         273
FT                   /evidence="ECO:0000313|EMBL:AGA84613.1"
SQ   SEQUENCE   273 AA;  31728 MW;  88640BBBB73B42EA CRC64;
     SHSMKYFFTS VSRPGRGEPR FISVGYVDDT QFVRFDSDAA SPRGEPRAPW VEQEGPEYWD
     RETQKYKRQA QTDRVSLRNL RGYYNQSEAG SHTLQWMCGC DLGPDGRLLR GYDQYAYDGK
     DYIALNEDLR SWTAADTAAQ ITQRKWEAAR EAEQRRAYLE GTCVEWLRRY LENGKETLQR
     AEHPKTHVTH HPVSDHEATL RCWALGFYPA EITLTWQWDG EDQTQDTELV ETRPAGDGTF
     QKWAAVMVPS GEEQRYTCHV QHEGLPEPLT LRW
//