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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Ena montana
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:COIImported
Encoded oniMitochondrionImported
OrganismiEna montanaImported
Taxonomic identifieri265227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraPanpulmonataEupulmonataStylommatophoraSigmurethraEnoideaEnidaeEna

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 24HelicalSequence analysisAdd BLAST20
Transmembranei44 – 67HelicalSequence analysisAdd BLAST24
Transmembranei88 – 112HelicalSequence analysisAdd BLAST25
Transmembranei132 – 157HelicalSequence analysisAdd BLAST26
Transmembranei169 – 196HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 207COX1InterPro annotationAdd BLAST207

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiView protein in InterPro
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR036927. Cyt_c_oxase-like_su1_sf.
IPR000883. Cyt_C_Oxase_1.
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiView protein in Pfam
PF00115. COX1. 1 hit.
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiView protein in PROSITE
PS50855. COX1. 1 hit.

Sequencei

Sequence statusi: Fragment.

L0CV84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DIGTLYMIFG VWCGMVGTGL SLLIRLELGT TGVLMDDHFY NVVVTAHAFV
60 70 80 90 100
MIFFMVMPIM IGGFGNWMIP LLIGAPDMSF PRMNNMSFWL LPPAFILLIS
110 120 130 140 150
SSLVEGGAGT GWTVYPPLSS LSGHGGASVD LAIFSLHLAG LSSILGAINF
160 170 180 190 200
ITTIFNMRAP SITLERMSLF VWSILVTVFL LLLSLPVLAG AITMLLTDRN

FNTSFFD
Length:207
Mass (Da):22,466
Last modified:March 6, 2013 - v1
Checksum:i7BD7CE62DBD46FAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei207Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX911299 Genomic DNA. Translation: AGA20283.1.

Similar proteinsi

Entry informationi

Entry nameiL0CV84_9EUPU
AccessioniPrimary (citable) accession number: L0CV84
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: October 25, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)