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Protein
Submitted name:

Toll-like receptor 4

Gene

Tlr4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorSAAS annotationImported
Biological processImmunity, Innate immunitySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Toll-like receptor 4Imported
Gene namesi
Name:Tlr4Imported
ORF Names:mCG_18008Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96824 Tlr4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei631 – 654HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501141974026 – 835Sequence analysisAdd BLAST810

Expressioni

Gene expression databases

BgeeiENSMUSG00000039005
ExpressionAtlasiL0CL36 baseline and differential

Structurei

3D structure databases

SMRiL0CL36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini670 – 816TIRInterPro annotationAdd BLAST147

Sequence similaritiesi

Belongs to the Toll-like receptor family.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
KOiK10160
OMAiEDWVRNE
OrthoDBiEOG091G01RC

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027168 TLR4
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR44568 PTHR44568, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

L0CL36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPPWLLART LIMALFFSCL TPGSLNPCIE VVPNITYQCM DQKLSKVPDD
60 70 80 90 100
IPSSTKNIDL SFNPLKILKS YSFSNFSELQ WLDLSRCEIE TIEDKAWHGL
110 120 130 140 150
HHLSNLILTG NPIQSFSPGS FSGLTSLENL VAVETKLASL ESFPIGQLIT
160 170 180 190 200
LKKLNVAHNF IHSCKLPAYF SNLTNLVHVD LSYNYIQTIT VNDLQFLREN
210 220 230 240 250
PQVNLSLDMS LNPIDFIQDQ AFQGIKLHEL TLRGNFNSSN IMKTCLQNLA
260 270 280 290 300
GLHVHRLILG EFKDERNLEI FEPSIMEGLC DVTIDEFRLT YTNDFSDDIV
310 320 330 340 350
KFHCLANVSA MSLAGVSIKY LEDVPKHFKW QSLSIIRCQL KQFPTLDLPF
360 370 380 390 400
LKSLTLTMNK GSISFKKVAL PSLSYLDLSR NALSFSGCCS YSDLGTNSLR
410 420 430 440 450
HLDLSFNGAI IMSANFMGLE ELQHLDFQHS TLKRVTEFSA FLSLEKLLYL
460 470 480 490 500
DISYTNTKID FDGIFLGLTS LNTLKMAGNS FKDNTLSNVF ANTTNLTFLD
510 520 530 540 550
LSKCQLEQIS WGVFDTLHRL QLLNMSHNNL LFLDSSHYNQ LYSLSTLDCS
560 570 580 590 600
FNRIETSKGI LQHFPKSLAF FNLTNNSVAC ICEHQKFLQW VKEQKQFLVN
610 620 630 640 650
VEQMTCATPV EMNTSLVLDF NNSTCYMYKT IISVSVVSVI VVSTVAFLIY
660 670 680 690 700
HFYFHLILIA GCKKYSRGES IYDAFVIYSS QNEDWVRNEL VKNLEEGVPR
710 720 730 740 750
FHLCLHYRDF IPGVAIAANI IQEGFHKSRK VIVVVSRHFI QSRWCIFEYE
760 770 780 790 800
IAQTWQFLSS RSGIIFIVLE KVEKSLLRQQ VELYRLLSRN TYLEWEDNPL
810 820 830
GRHIFWRRLK NALLDGKASN PEQTAEEEQE TATWT
Length:835
Mass (Da):95,519
Last modified:March 6, 2013 - v1
Checksum:i9C83B59F9A220C17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX878359 mRNA Translation: AGA16686.1
CH466527 Genomic DNA Translation: EDL31078.1
RefSeqiNP_067272.1, NM_021297.3
UniGeneiMm.38049

Genome annotation databases

GeneIDi21898
KEGGimmu:21898

Similar proteinsi

Entry informationi

Entry nameiL0CL36_MOUSE
AccessioniPrimary (citable) accession number: L0CL36
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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