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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Anabaena cylindrica (strain ATCC 27899 / PCC 7122)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi159 – 166ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation
Biological processDNA replicationUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotationSAAS annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:Anacy_0001Imported
ORF Names:NIES19_12050Imported
OrganismiAnabaena cylindrica (strain ATCC 27899 / PCC 7122)Imported
Taxonomic identifieri272123 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
Proteomesi
  • UP000010474 Componenti: Chromosome

Subcellular locationi

K9Z8X1:
  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 279AAAInterPro annotationAdd BLAST129
Domaini360 – 429Bac_DnaA_CInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK02313.
OMAiREFNPLF.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
PANTHERiPTHR30050:SF2. PTHR30050:SF2. 1 hit.
PfamiView protein in Pfam
PF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
PRINTSiPR00051. DNAA.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiView protein in PROSITE
PS01008. DNAA. 1 hit.

Sequencei

Sequence statusi: Complete.

K9Z8X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPIDSLWS QVLERLQLEL SRPTFETWIK TASAEQLENN CLVIRTPNPF
60 70 80 90 100
ARNWLQKYYI NTIAHVVQDI LGYPVEIYIT VAQGDEVSQL GKQEVAWELP
110 120 130 140 150
AVNPIFTNVS KNQQKTTELN PKYVFSRFVV GANNRMAHAA SLAVAEYPGR
160 170 180 190 200
EFNPLFLCGG VGLGKTHLMQ AIGNYRWEIY PNSKIFYVST EQFTNDLITA
210 220 230 240 250
IRNDSMQIFR EHYRAADVLL VDDIQFLEGK EYTQEEFFHT FNTLHESGKQ
260 270 280 290 300
VVIASDRPPN QIPSLQERLC SRFSMGLIAD IQSPDLETRM AILQKKAEYE
310 320 330 340 350
NIRLPKDVIE YIACNYTSNI RELEGALIRA LAYISIWGLA MTVENITPVL
360 370 380 390 400
GTSNQKLEVT PDVILKVIAE SFDISIEDLK SNSRRREISW ARQIGMYLMR
410 420 430 440 450
QLTGLSLPRI GEEFGGKDHT TVMYSCEKIT QLQETDRSLI QTLRQLSDRI

NMNSRSQK
Length:458
Mass (Da):52,474
Last modified:March 6, 2013 - v1
Checksum:iB95AC3D2C6E05E77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003659 Genomic DNA. Translation: AFZ55616.1.
AP018166 Genomic DNA. Translation: BAY01969.1.
RefSeqiWP_015212273.1. NC_019771.1.

Genome annotation databases

EnsemblBacteriaiAFZ55616; AFZ55616; Anacy_0001.
KEGGiacy:Anacy_0001.
PATRICifig|272123.3.peg.1.

Similar proteinsi

Entry informationi

Entry nameiK9Z8X1_ANACC
AccessioniPrimary (citable) accession number: K9Z8X1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: October 25, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported