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K9YI74

- K9YI74_CYASC

UniProt

K9YI74 - K9YI74_CYASC

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Protein

Ribulose bisphosphate carboxylase large chain

Gene
cbbL, rbcL, Cyast_0117
Organism
Cyanobacterium stanieri (strain ATCC 29140 / PCC 7202)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Substrate; in homodimeric partner By similarityUniRule annotation
Binding sitei166 – 1661Substrate By similarityUniRule annotation
Active sitei168 – 1681Proton acceptor By similarityUniRule annotation
Binding sitei170 – 1701Substrate By similarityUniRule annotation
Metal bindingi194 – 1941Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi196 – 1961Magnesium By similarityUniRule annotation
Metal bindingi197 – 1971Magnesium By similarityUniRule annotation
Active sitei287 – 2871Proton acceptor By similarityUniRule annotation
Binding sitei288 – 2881Substrate By similarityUniRule annotation
Binding sitei320 – 3201Substrate By similarityUniRule annotation
Sitei327 – 3271Transition state stabilizer By similarityUniRule annotation
Binding sitei372 – 3721Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. monooxygenase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. photorespiration Source: UniProtKB-KW
  2. reductive pentose-phosphate cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Biological processi

Calvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation, PhotorespirationUniRule annotation, PhotosynthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotation
Synonyms:rbcLUniRule annotation
Ordered Locus Names:Cyast_0117Imported
OrganismiCyanobacterium stanieri (strain ATCC 29140 / PCC 7202)Imported
Taxonomic identifieri292563 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanobacterium
ProteomesiUP000010483: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei194 – 1941N6-carboxylysine By similarityUniRule annotation
Disulfide bondi240 – 240Interchain; in linked form By similarityUniRule annotation

Post-translational modificationi

The disulfide bond which can form in the large chain dimeric partners within the hexadecamer appears to be associated with oxidative stress and protein turnover By similarity.UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains; disulfide-linked. The disulfide link is formed within the large subunit homodimers By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01601.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01338. RuBisCO_L_type1.
InterProiIPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K9YI74-1 [UniParc]FASTAAdd to Basket

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MAQAGFKAGV QDYRLTYYTP DYTPKDTDLL ACFRMTPQPG VPPEECAAAV    50
AAESSTGTWT TVWTDGLTDL DRYKGRCYNV EPVPGEDNQY FCFVAYPLDL 100
FEEGSVTNVL TSLVGNVFGF KALRALRLED IRFPVALIKT YQGPPHGITV 150
ERDLLNKYGR PLLGCTIKPK LGLSAKNYGR AVYECLRGGL DFTKDDENIN 200
SQPFMRWRDR FLFVQEAIEK AQAETNEIKG HYLNVTAGTC EEMMKRAEFA 250
KEIGTPIIMH DFLTGGFTAN TTLAKWCRDN GVLLHIHRAM HAVIDRQKNH 300
GIHFRVLAKC LRLSGGDHLH SGTVVGKLEG DRAGTLGFVD LMREDYVEED 350
RSRGVFFTQD YASLPGTMPV ASGGIHVWHM PALVEIFGDD SCLQFGGGTL 400
GHPWGNAPGA TANRVALEAC VQARNEGRSL AREGNDVIRE ACRWSPELAA 450
ACELWKEIKF EFDTVDTL 468
Length:468
Mass (Da):52,008
Last modified:March 6, 2013 - v1
Checksum:iC08787527E9C3424
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003940 Genomic DNA. Translation: AFZ46100.1.
RefSeqiYP_007163749.1. NC_019778.1.

Genome annotation databases

EnsemblBacteriaiAFZ46100; AFZ46100; Cyast_0117.
GeneIDi14198481.
KEGGicsn:Cyast_0117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003940 Genomic DNA. Translation: AFZ46100.1 .
RefSeqi YP_007163749.1. NC_019778.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFZ46100 ; AFZ46100 ; Cyast_0117 .
GeneIDi 14198481.
KEGGi csn:Cyast_0117.

Phylogenomic databases

KOi K01601.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01338. RuBisCO_L_type1.
InterProi IPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29140 / PCC 7202.

Entry informationi

Entry nameiK9YI74_CYASC
AccessioniPrimary (citable) accession number: K9YI74
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: July 9, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel" By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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