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Protein

Hydroxyacylglutathione hydrolase

Gene

gloB

Organism
Chroococcidiopsis thermalis PCC 7203
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.UniRule annotationSAAS annotation

Catalytic activityi

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi: methylglyoxal degradation

This protein is involved in step 2 of the subpathway that synthesizes (R)-lactate from methylglyoxal.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Hydroxyacylglutathione hydrolase (gloB)
This subpathway is part of the pathway methylglyoxal degradation, which is itself part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-lactate from methylglyoxal, the pathway methylglyoxal degradation and in Secondary metabolite metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Zinc 1UniRule annotation1
Metal bindingi56Zinc 1UniRule annotation1
Metal bindingi58Zinc 2UniRule annotation1
Metal bindingi59Zinc 2UniRule annotation1
Metal bindingi113Zinc 1UniRule annotation1
Metal bindingi137Zinc 1UniRule annotation1
Metal bindingi137Zinc 2UniRule annotation1
Metal bindingi175Zinc 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
LigandMetal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCTHE251229:G1HCP-5020-MONOMER.
UniPathwayiUPA00619; UER00676.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyacylglutathione hydrolaseUniRule annotation (EC:3.1.2.6UniRule annotation)
Alternative name(s):
Glyoxalase IIUniRule annotation
Short name:
Glx IIUniRule annotation
Gene namesi
Name:gloBUniRule annotation
ORF Names:Chro_5039Imported
OrganismiChroococcidiopsis thermalis PCC 7203Imported
Taxonomic identifieri251229 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaChroococcidiopsidalesChroococcidiopsidaceaeChroococcidiopsis
Proteomesi
  • UP000010384 Componenti: Chromosome

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 175Lactamase_BInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01069.
OrthoDBiPOG091H03YM.

Family and domain databases

CDDicd07723. hydroxyacylglutathione_hydrola. 1 hit.
Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01374. Glyoxalase_2. 1 hit.
InterProiView protein in InterPro
IPR035680. Clx_II_MBL.
IPR032282. HAGH_C.
IPR017782. Hydroxyacylglutathione_Hdrlase.
IPR001279. Metallo-B-lactamas.
IPR036866. RibonucZ/Hydroxyglut_hydro.
PfamiView protein in Pfam
PF16123. HAGH_C. 1 hit.
PF00753. Lactamase_B. 1 hit.
PIRSFiPIRSF005457. Glx. 1 hit.
SMARTiView protein in SMART
SM00849. Lactamase_B. 1 hit.
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR03413. GSH_gloB. 1 hit.

Sequencei

Sequence statusi: Complete.

K9U7L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVIRLNALS DNYIFLLYEP QQNIAAVVDP AEAEPVLKQL QQLGAELVAI
60 70 80 90 100
FNTHHHHDHV GGNQKLMQKF PQLTVYGGVE DKGRIPGQKV FLQEGDRVSF
110 120 130 140 150
GNRTGEVFFV PGHTRAHIAY YFPPTSVNEP GELFCGDTLF AGGCGRLFEG
160 170 180 190 200
TPTQMVNSLS KLRNLPDNTR VWCAHEYTLK NLQFALTVDG NNSELRSRFA
210 220 230 240 250
QVQEARDRNR ATVPSLLGIE KQTNPFLRWQ QPELQAAVKS QDPVQTFARL

RGMKDRF
Length:257
Mass (Da):28,991
Last modified:March 6, 2013 - v1
Checksum:i8DC4D8C0293D2189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003597 Genomic DNA. Translation: AFY90416.1.
RefSeqiWP_015156954.1. NC_019695.1.

Genome annotation databases

EnsemblBacteriaiAFY90416; AFY90416; Chro_5039.
KEGGicthe:Chro_5039.
PATRICifig|251229.3.peg.5881.

Similar proteinsi

Entry informationi

Entry nameiK9U7L0_9CYAN
AccessioniPrimary (citable) accession number: K9U7L0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: February 28, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported