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Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Pseudanabaena sp. PCC 7367
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei118Substrate; in homodimeric partnerUniRule annotation1
Binding sitei168SubstrateUniRule annotation1
Active sitei170Proton acceptorUniRule annotation1
Binding sitei172SubstrateUniRule annotation1
Metal bindingi196Magnesium; via carbamate groupUniRule annotation1
Metal bindingi198MagnesiumUniRule annotation1
Metal bindingi199MagnesiumUniRule annotation1
Active sitei289Proton acceptorUniRule annotation1
Binding sitei290SubstrateUniRule annotation1
Binding sitei322SubstrateUniRule annotation1
Sitei329Transition state stabilizerUniRule annotation1
Binding sitei374SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Biological processi

Calvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation, PhotorespirationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotation
Synonyms:rbcLUniRule annotation
ORF Names:Pse7367_0918Imported
OrganismiPseudanabaena sp. PCC 7367Imported
Taxonomic identifieri82654 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesPseudanabaenaceaePseudanabaena
Proteomesi
  • UP000010386 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196N6-carboxylysineUniRule annotation1

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 139RuBisCO_large_NInterPro annotationAdd BLAST121
Domaini149 – 457RuBisCO_largeInterPro annotationAdd BLAST309

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

KOiK01601.
OrthoDBiPOG091H14UZ.

Family and domain databases

CDDicd08212. RuBisCO_large_I. 1 hit.
Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01338. RuBisCO_L_type1. 1 hit.
InterProiIPR033966. RuBisCO.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR020888. RuBisCO_lsuI.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K9SG91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTTKGFQA GVKDYKLTYY TPDYTPKDTD ILAAFRMTPQ PGVPPEEAGA
60 70 80 90 100
AVAAESSTGT WTTVWTDLLT DLDRYKGRCY DVESVPGEDN QYIAYVAYPL
110 120 130 140 150
DLFEEGSVTN MLTSIVGNVF GFKALRALRL EDLRIPVAYL KTFEGPPHGI
160 170 180 190 200
VVERDKLNKY GRPLLGCTIK PKLGLSAKNY GRACYEILRG GLDFTKDDEN
210 220 230 240 250
INSQPFMRWR DRFLFVADAI HKAQAETGEI KGHYLNCTAA TVEEMMKRAE
260 270 280 290 300
FAKELEMPIV MHDFLTAGFT ANTTLSKWCR NNGMLLHIHR AMHAVIDRQK
310 320 330 340 350
NHGMHFRVLA KCLRMSGGDH IHTGTVVGKL EGDRASTLGF VDLLRENYVE
360 370 380 390 400
QDKSRGIYFT QDWASMGGVF AVASGGIHVW HMPALVEIFG DDSVLQFGGG
410 420 430 440 450
TLGHPWGNAP GAVANRVALE ACVQARNEGR NLNREGADII REAARWSPEL
460 470
AVACETWKEI KFEFDTVDTL
Length:470
Mass (Da):52,305
Last modified:March 6, 2013 - v1
Checksum:i067933F733FF88E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003592 Genomic DNA. Translation: AFY69218.1.
RefSeqiWP_015164191.1. NC_019701.1.

Genome annotation databases

EnsemblBacteriaiAFY69218; AFY69218; Pse7367_0918.
KEGGipseu:Pse7367_0918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003592 Genomic DNA. Translation: AFY69218.1.
RefSeqiWP_015164191.1. NC_019701.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFY69218; AFY69218; Pse7367_0918.
KEGGipseu:Pse7367_0918.

Phylogenomic databases

KOiK01601.
OrthoDBiPOG091H14UZ.

Family and domain databases

CDDicd08212. RuBisCO_large_I. 1 hit.
Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01338. RuBisCO_L_type1. 1 hit.
InterProiIPR033966. RuBisCO.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR020888. RuBisCO_lsuI.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK9SG91_9CYAN
AccessioniPrimary (citable) accession number: K9SG91
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: November 30, 2016
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.