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Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Pseudanabaena sp. PCC 7367
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Substrate; in homodimeric partnerUniRule annotation
Binding sitei168 – 1681SubstrateUniRule annotation
Active sitei170 – 1701Proton acceptorUniRule annotation
Binding sitei172 – 1721SubstrateUniRule annotation
Metal bindingi196 – 1961Magnesium; via carbamate groupUniRule annotation
Metal bindingi198 – 1981MagnesiumUniRule annotation
Metal bindingi199 – 1991MagnesiumUniRule annotation
Active sitei289 – 2891Proton acceptorUniRule annotation
Binding sitei290 – 2901SubstrateUniRule annotation
Binding sitei322 – 3221SubstrateUniRule annotation
Sitei329 – 3291Transition state stabilizerUniRule annotation
Binding sitei374 – 3741SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Biological processi

Calvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation, PhotorespirationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotation
Synonyms:rbcLUniRule annotation
ORF Names:Pse7367_0918Imported
OrganismiPseudanabaena sp. PCC 7367Imported
Taxonomic identifieri82654 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesPseudanabaena
ProteomesiUP000010386 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei196 – 1961N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

KOiK01601.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01338. RuBisCO_L_type1.
InterProiIPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K9SG91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTTKGFQA GVKDYKLTYY TPDYTPKDTD ILAAFRMTPQ PGVPPEEAGA
60 70 80 90 100
AVAAESSTGT WTTVWTDLLT DLDRYKGRCY DVESVPGEDN QYIAYVAYPL
110 120 130 140 150
DLFEEGSVTN MLTSIVGNVF GFKALRALRL EDLRIPVAYL KTFEGPPHGI
160 170 180 190 200
VVERDKLNKY GRPLLGCTIK PKLGLSAKNY GRACYEILRG GLDFTKDDEN
210 220 230 240 250
INSQPFMRWR DRFLFVADAI HKAQAETGEI KGHYLNCTAA TVEEMMKRAE
260 270 280 290 300
FAKELEMPIV MHDFLTAGFT ANTTLSKWCR NNGMLLHIHR AMHAVIDRQK
310 320 330 340 350
NHGMHFRVLA KCLRMSGGDH IHTGTVVGKL EGDRASTLGF VDLLRENYVE
360 370 380 390 400
QDKSRGIYFT QDWASMGGVF AVASGGIHVW HMPALVEIFG DDSVLQFGGG
410 420 430 440 450
TLGHPWGNAP GAVANRVALE ACVQARNEGR NLNREGADII REAARWSPEL
460 470
AVACETWKEI KFEFDTVDTL
Length:470
Mass (Da):52,305
Last modified:March 6, 2013 - v1
Checksum:i067933F733FF88E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003592 Genomic DNA. Translation: AFY69218.1.
RefSeqiWP_015164191.1. NC_019701.1.

Genome annotation databases

EnsemblBacteriaiAFY69218; AFY69218; Pse7367_0918.
KEGGipseu:Pse7367_0918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003592 Genomic DNA. Translation: AFY69218.1.
RefSeqiWP_015164191.1. NC_019701.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFY69218; AFY69218; Pse7367_0918.
KEGGipseu:Pse7367_0918.

Phylogenomic databases

KOiK01601.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01338. RuBisCO_L_type1.
InterProiIPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PCC 7367Imported.

Entry informationi

Entry nameiK9SG91_9CYAN
AccessioniPrimary (citable) accession number: K9SG91
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: July 22, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.