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K8FDN9

- K8FDN9_LISMN

UniProt

K8FDN9 - K8FDN9_LISMN

Protein

Thymidine kinase

Gene

tdk

Organism
Listeria monocytogenes serotype 4b str. LL195
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (06 Feb 2013)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei120 – 1201Proton acceptorUniRule annotation
    Metal bindingi177 – 1771ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation
    Metal bindingi215 – 2151ZincUniRule annotation
    Metal bindingi218 – 2181ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi43 – 508ATPUniRule annotation
    Nucleotide bindingi119 – 1224ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    ORF Names:BN389_25060Imported
    OrganismiListeria monocytogenes serotype 4b str. LL195Imported
    Taxonomic identifieri1230340 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000009396: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    K8FDN9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLCGVAFFN YMSQFVPLYD KIGKEFIKLK GAVLMAQLFF RYGSMNSGKT    50
    IEILKVAHNY EEQNKTVAIF TSGIDDRDQV GFISSRIGLK REATPIFSDT 100
    NIFEIVANIK PKPNCVLLDE SQFLEKEHVF QLAKIVDELN IPVIAYGLKN 150
    DFRNELFEGS KYLLLYADKL EEMKTICWFC AKKATMVLRV DDKGKPVYTG 200
    EQIMIGGNDH YYPVCRKCHA NPPIK 225
    Length:225
    Mass (Da):25,700
    Last modified:February 6, 2013 - v1
    Checksum:iCB37BBB464DD5548
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HF558398 Genomic DNA. Translation: CCO65080.1.
    RefSeqiWP_015085130.1. NC_019556.1.
    YP_007016071.1. NC_019556.1.

    Genome annotation databases

    EnsemblBacteriaiCCO65080; CCO65080; BN389_25060.
    GeneIDi14020078.
    KEGGilmog:BN389_25060.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HF558398 Genomic DNA. Translation: CCO65080.1 .
    RefSeqi WP_015085130.1. NC_019556.1.
    YP_007016071.1. NC_019556.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCO65080 ; CCO65080 ; BN389_25060 .
    GeneIDi 14020078.
    KEGGi lmog:BN389_25060.

    Phylogenomic databases

    KOi K00857.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Listeria monocytogenes LL195 - a serotype 4b strain from the 1983 to 1987 listeriosis epidemic in Switzerland."
      Weinmaier T., Riesing M., Rattei T., Bille J., Arguedas-Villa C., Stephan R., Tasara T.
      Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LL195Imported.

    Entry informationi

    Entry nameiK8FDN9_LISMN
    AccessioniPrimary (citable) accession number: K8FDN9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2013
    Last sequence update: February 6, 2013
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3