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K8FDN9

- K8FDN9_LISMN

UniProt

K8FDN9 - K8FDN9_LISMN

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Protein

Thymidine kinase

Gene

tdk

Organism
Listeria monocytogenes serotype 4b str. LL195
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei120 – 1201Proton acceptorUniRule annotation
Metal bindingi177 – 1771ZincUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation
Metal bindingi215 – 2151ZincUniRule annotation
Metal bindingi218 – 2181ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508ATPUniRule annotation
Nucleotide bindingi119 – 1224ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:BN389_25060Imported
OrganismiListeria monocytogenes serotype 4b str. LL195Imported
Taxonomic identifieri1230340 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000009396: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K8FDN9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLCGVAFFN YMSQFVPLYD KIGKEFIKLK GAVLMAQLFF RYGSMNSGKT
60 70 80 90 100
IEILKVAHNY EEQNKTVAIF TSGIDDRDQV GFISSRIGLK REATPIFSDT
110 120 130 140 150
NIFEIVANIK PKPNCVLLDE SQFLEKEHVF QLAKIVDELN IPVIAYGLKN
160 170 180 190 200
DFRNELFEGS KYLLLYADKL EEMKTICWFC AKKATMVLRV DDKGKPVYTG
210 220
EQIMIGGNDH YYPVCRKCHA NPPIK
Length:225
Mass (Da):25,700
Last modified:February 6, 2013 - v1
Checksum:iCB37BBB464DD5548
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HF558398 Genomic DNA. Translation: CCO65080.1.
RefSeqiYP_007016071.1. NC_019556.1.

Genome annotation databases

EnsemblBacteriaiCCO65080; CCO65080; BN389_25060.
GeneIDi14020078.
KEGGilmog:BN389_25060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HF558398 Genomic DNA. Translation: CCO65080.1 .
RefSeqi YP_007016071.1. NC_019556.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCO65080 ; CCO65080 ; BN389_25060 .
GeneIDi 14020078.
KEGGi lmog:BN389_25060.

Phylogenomic databases

KOi K00857.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Listeria monocytogenes LL195 - a serotype 4b strain from the 1983 to 1987 listeriosis epidemic in Switzerland."
    Weinmaier T., Riesing M., Rattei T., Bille J., Arguedas-Villa C., Stephan R., Tasara T.
    Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LL195Imported.

Entry informationi

Entry nameiK8FDN9_LISMN
AccessioniPrimary (citable) accession number: K8FDN9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2013
Last sequence update: February 6, 2013
Last modified: November 26, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3