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K8FDN9

- K8FDN9_LISMN

UniProt

K8FDN9 - K8FDN9_LISMN

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Protein
Thymidine kinase
Gene
tdk, BN389_25060
Organism
Listeria monocytogenes serotype 4b str. LL195
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei120 – 1201Proton acceptor By similarityUniRule annotation
Metal bindingi177 – 1771Zinc By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation
Metal bindingi215 – 2151Zinc By similarityUniRule annotation
Metal bindingi218 – 2181Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508ATP By similarityUniRule annotation
Nucleotide bindingi119 – 1224ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:BN389_25060Imported
OrganismiListeria monocytogenes serotype 4b str. LL195Imported
Taxonomic identifieri1230340 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000009396: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K8FDN9-1 [UniParc]FASTAAdd to Basket

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MPLCGVAFFN YMSQFVPLYD KIGKEFIKLK GAVLMAQLFF RYGSMNSGKT    50
IEILKVAHNY EEQNKTVAIF TSGIDDRDQV GFISSRIGLK REATPIFSDT 100
NIFEIVANIK PKPNCVLLDE SQFLEKEHVF QLAKIVDELN IPVIAYGLKN 150
DFRNELFEGS KYLLLYADKL EEMKTICWFC AKKATMVLRV DDKGKPVYTG 200
EQIMIGGNDH YYPVCRKCHA NPPIK 225
Length:225
Mass (Da):25,700
Last modified:February 6, 2013 - v1
Checksum:iCB37BBB464DD5548
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HF558398 Genomic DNA. Translation: CCO65080.1.
RefSeqiWP_015085130.1. NC_019556.1.
YP_007016071.1. NC_019556.1.

Genome annotation databases

EnsemblBacteriaiCCO65080; CCO65080; BN389_25060.
GeneIDi14020078.
KEGGilmog:BN389_25060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HF558398 Genomic DNA. Translation: CCO65080.1 .
RefSeqi WP_015085130.1. NC_019556.1.
YP_007016071.1. NC_019556.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCO65080 ; CCO65080 ; BN389_25060 .
GeneIDi 14020078.
KEGGi lmog:BN389_25060.

Phylogenomic databases

KOi K00857.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Listeria monocytogenes LL195 - a serotype 4b strain from the 1983 to 1987 listeriosis epidemic in Switzerland."
    Weinmaier T., Riesing M., Rattei T., Bille J., Arguedas-Villa C., Stephan R., Tasara T.
    Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LL195Imported.

Entry informationi

Entry nameiK8FDN9_LISMN
AccessioniPrimary (citable) accession number: K8FDN9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2013
Last sequence update: February 6, 2013
Last modified: September 3, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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