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Protein
Submitted name:

MHC class I antigen

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:HLA-AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei308 – 332HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501067970625 – 365Sequence analysisAdd BLAST341

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

SMRiK7WT83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 297Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

K7WT83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMPPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDSQFVQF DSDAASQRME PRAPWIEQEE PEYWDEETRN VKAHSQTNRA
110 120 130 140 150
NLGTLRGYYN QSEDGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAARRAEQL RAYLEGECVD GLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGKEKR YTCHVQHEGL PEPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VIAGAVVAAV MWRKKSSVRK GGSYSQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,792
Last modified:February 6, 2013 - v1
Checksum:iCE1BC1CD60CA8FA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX009131 Genomic DNA. Translation: AFU35545.1.
JX826590 Genomic DNA. Translation: AFW99834.1.
HG965149 Genomic DNA. Translation: CDO33937.1.
LN877360 Genomic DNA. Translation: CUA55103.1.
UniGeneiHs.181244.
Hs.713441.

Similar proteinsi

Entry informationi

Entry nameiK7WT83_HUMAN
AccessioniPrimary (citable) accession number: K7WT83
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2013
Last sequence update: February 6, 2013
Last modified: September 27, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.