ID   K7W4Q0_9NOST            Unreviewed;       591 AA.
AC   K7W4Q0;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=Alkaline phosphatase {ECO:0000313|EMBL:AFW95972.1};
DE            EC=3.1.3.1 {ECO:0000313|EMBL:AFW95972.1};
GN   Name=phoA {ECO:0000313|EMBL:AFW95972.1};
GN   ORFNames=ANA_C13296 {ECO:0000313|EMBL:AFW95972.1};
OS   Anabaena sp. 90.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=46234 {ECO:0000313|EMBL:AFW95972.1, ECO:0000313|Proteomes:UP000010101};
RN   [1] {ECO:0000313|EMBL:AFW95972.1, ECO:0000313|Proteomes:UP000010101}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=90 {ECO:0000313|EMBL:AFW95972.1};
RX   PubMed=23148582; DOI=10.1186/1471-2164-13-613;
RA   Wang H., Sivonen K., Rouhiainen L., Fewer D.P., Lyra C., Rantala-Ylinen A.,
RA   Vestola J., Jokela J., Rantasarkka K., Li Z., Liu B.;
RT   "Genome-derived insights into the biology of the hepatotoxic bloom-forming
RT   cyanobacterium Anabaena sp. strain 90.";
RL   BMC Genomics 13:613-613(2012).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR601952-2};
CC       Note=Binds 1 Mg(2+) ion. {ECO:0000256|PIRSR:PIRSR601952-2};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR601952-2};
CC       Note=Binds 2 Zn(2+) ions. {ECO:0000256|PIRSR:PIRSR601952-2};
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DR   EMBL; CP003284; AFW95972.1; -; Genomic_DNA.
DR   RefSeq; WP_015081115.1; NC_019427.1.
DR   AlphaFoldDB; K7W4Q0; -.
DR   STRING; 46234.ANA_C13296; -.
DR   KEGG; anb:ANA_C13296; -.
DR   PATRIC; fig|46234.3.peg.3742; -.
DR   eggNOG; COG1785; Bacteria.
DR   HOGENOM; CLU_018809_0_0_3; -.
DR   OrthoDB; 9794455at2; -.
DR   Proteomes; UP000010101; Chromosome chANA01.
DR   GO; GO:0004035; F:alkaline phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd16012; ALP; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR   InterPro; IPR001952; Alkaline_phosphatase.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   PANTHER; PTHR11596; ALKALINE PHOSPHATASE; 1.
DR   PANTHER; PTHR11596:SF5; ALKALINE PHOSPHATASE; 1.
DR   Pfam; PF00245; Alk_phosphatase; 1.
DR   SMART; SM00098; alkPPc; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:AFW95972.1};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR601952-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR601952-2};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010101};
KW   Zinc {ECO:0000256|PIRSR:PIRSR601952-2}.
FT   ACT_SITE        182
FT                   /note="Phosphoserine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
FT   BINDING         233
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT   BINDING         235
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT   BINDING         436
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT   BINDING         441
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT   BINDING         445
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT   BINDING         486
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT   BINDING         487
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
SQ   SEQUENCE   591 AA;  63824 MW;  96072B6DD8A95A67 CRC64;
     MVIKSSSQFR FKRRLFTTVL IIVVGIFITL TNHSSPATPV TKTKNVILMI GDGMGWEMAR
     AGAMAKGYNY TSGKGEGLSF QTLDNYALAT TYGTTIAPGN GVFSTGNSAL SNSNPITGAS
     PILPGFKFQP QFNPGDKPSG GGKNLNPNAV GNLVGYDPQR GGINPWTPGN DPEYIKYSYP
     DSANTATTLY TGVKSYNNAI SVDIFEKPLE TILKTAADHG KSTGIVTSVP VDHATPGAAA
     ANVNRRNKYD GDYPTLDNIL QQELRIYQPT VILGGGHPLT GASSQPLPTG VEPPTKFEYI
     TKTTYAELSK NPNQNRYNYT FLERGKDAAD KLATTAAKLD PNMGDRLLGL YGARGQEGNL
     PVSTANGDYS NTGLSNFSLF SSQGQKPDTV RPLLAGETDQ SFIAKEINEN PTLDDLTKAA
     LAVLSKDKDG FWLMVEGGDI DWAAHDDNID NMIGTVLDFD KAVKTTIDWI KNNGGWENNL
     LIVTADHDHY LTLNPNFSEL LKEKSAEALT AESDSMKAGH FWGSNPQIKY GWGNHGNRPV
     PVYYQGKGAE VLTNSVGKGF RLYGDDIPGI GGLVDQIHIY QTQRKAIGNR E
//