UniProtKB - K7Q7T7 (K7Q7T7_MOUSE)
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Protein
Submitted name:
RAS-related C3 botulinum substrate 1
Gene
Rac1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- GTPase activity Source: Ensembl
- GTP binding Source: UniProtKB-KW
- GTP-dependent protein binding Source: Ensembl
GO - Biological processi
- actin filament polymerization Source: Ensembl
- anatomical structure arrangement Source: Ensembl
- auditory receptor cell morphogenesis Source: Ensembl
- axon guidance Source: Ensembl
- cell-cell junction organization Source: Ensembl
- cerebral cortex GABAergic interneuron development Source: Ensembl
- cerebral cortex radially oriented cell migration Source: Ensembl
- cochlea morphogenesis Source: Ensembl
- dendrite morphogenesis Source: Ensembl
- embryonic olfactory bulb interneuron precursor migration Source: Ensembl
- engulfment of apoptotic cell Source: Ensembl
- epithelial cell morphogenesis Source: Ensembl
- G-protein coupled receptor signaling pathway Source: Ensembl
- homeostasis of number of cells within a tissue Source: Ensembl
- hyperosmotic response Source: Ensembl
- lamellipodium assembly Source: Ensembl
- midbrain dopaminergic neuron differentiation Source: Ensembl
- positive regulation of actin filament polymerization Source: Ensembl
- positive regulation of dendritic spine development Source: Ensembl
- positive regulation of neutrophil chemotaxis Source: Ensembl
- positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
- protein localization to plasma membrane Source: Ensembl
- regulation of cell morphogenesis Source: Ensembl
- regulation of fibroblast migration Source: Ensembl
- regulation of neuronal synaptic plasticity Source: Ensembl
- regulation of neuron maturation Source: Ensembl
- ruffle assembly Source: Ensembl
- small GTPase mediated signal transduction Source: Ensembl
- substrate adhesion-dependent cell spreading Source: Ensembl
- synaptic transmission, GABAergic Source: Ensembl
- Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
Keywordsi
| Ligand | GTP-bindingSAAS annotation, Nucleotide-binding |
Names & Taxonomyi
| Protein namesi | Submitted name: RAS-related C3 botulinum substrate 1ImportedSubmitted name: RAS-related C3 botulinum substrate 1, isoform CRA_cImported |
| Gene namesi | Name:Rac1Imported ORF Names:mCG_23557Imported |
| Organismi | Mus musculus (Mouse)Imported |
| Taxonomic identifieri | 10090 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
| MGIi | MGI:97845. Rac1. |
Subcellular locationi
GO - Cellular componenti
- early endosome membrane Source: Ensembl
- extrinsic component of plasma membrane Source: Ensembl
- kinocilium Source: Ensembl
- lamellipodium Source: Ensembl
- nucleus Source: Ensembl
- pericentriolar material Source: Ensembl
- phagocytic cup Source: Ensembl
- ruffle membrane Source: Ensembl
Keywords - Cellular componenti
MembraneSAAS annotationExpressioni
Gene expression databases
| Bgeei | ENSMUSG00000001847. |
| ExpressionAtlasi | K7Q7T7. baseline and differential. |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
| eggNOGi | KOG0393. Eukaryota. COG1100. LUCA. |
| KOi | K04392. |
Family and domain databases
| InterProi | View protein in InterPro IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003578. Small_GTPase_Rho. |
| Pfami | View protein in Pfam PF00071. Ras. 1 hit. |
| SUPFAMi | SSF52540. SSF52540. 1 hit. |
| TIGRFAMsi | TIGR00231. small_GTP. 1 hit. |
| PROSITEi | View protein in PROSITE PS51420. RHO. 1 hit. |
Sequencei
Sequence statusi: Complete.
K7Q7T7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP
60 70 80 90 100
VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE
110 120 130 140 150
VRHHCPNTPI ILVGTKLDLR DDKDTIEKLK EKKLTPITYP QGLAMAKEIG
160 170 180 190
AVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKRKRKCL LL
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JN971018 mRNA. Translation: AFR23587.1. CH466529 Genomic DNA. Translation: EDL19048.1. |
| RefSeqi | NP_033033.1. NM_009007.2. |
| UniGenei | Mm.292510. Mm.469963. Mm.475073. |
Genome annotation databases
| GeneIDi | 19353. |
| KEGGi | mmu:19353. |
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | K7Q7T7_MOUSE | |
| Accessioni | K7Q7T7Primary (citable) accession number: K7Q7T7 | |
| Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2013 |
| Last sequence update: | February 6, 2013 | |
| Last modified: | July 5, 2017 | |
| This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
