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Protein

Malate dehydrogenase

Gene

LOC100119291

Organism
Nasonia vitripennis (Parasitic wasp)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:LOC100119291Imported
OrganismiNasonia vitripennis (Parasitic wasp)Imported
Taxonomic identifieri7425 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaChalcidoideaPteromalidaePteromalinaeNasonia
ProteomesiUP000002358 Componenti: Chromosome 1

Structurei

3D structure databases

ProteinModelPortaliK7J699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

InParanoidiK7J699.
KOiK00025.
PhylomeDBiK7J699.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR011274. Malate_DH_NAD-dep_euk.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
TIGR01758. MDH_euk_cyt. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K7J699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPINVVVT GAAGQIAYSL LYQLAAGSVF GPDQPINLRL LDIEPMMGVL
60 70 80 90 100
KGVVMELEDL ALPLLKDVLP TADPEPAFKD AAAVFLVGSM PRREGMERKD
110 120 130 140 150
LLAANVKIFK IQGEALDKFA RKDVKVLVVG NPANTNALIC SHYAPSIPKE
160 170 180 190 200
NFTAMTRLDQ NRAQAAIAAR LGVAIDKVKN VIIWGNHSST QYPDAAQATV
210 220 230 240 250
EVNGTSKPVP EVVKDDKWLN EVFVETIQKR GAAVIAARKM SSAMSAAKAA
260 270 280 290 300
GDHMRDWWFG TKPGQYVSMG VVSDGSYGIP KDIVFSLPVT IQNKQYKIVQ
310 320 330
GLNISSFARS KLDITAKELE EERAEANTVL QQ
Length:332
Mass (Da):35,931
Last modified:January 9, 2013 - v1
Checksum:iCCC586AAB60716BA
GO

Sequence databases

RefSeqiXP_001605157.1. XM_001605107.3.
XP_008211006.1. XM_008212784.1.
XP_008211007.1. XM_008212785.1.
XP_008211008.1. XM_008212786.1.

Genome annotation databases

EnsemblMetazoaiNV16898-RA; NV16898-PA; NV16898.
GeneIDi100119291.
KEGGinvi:100119291.

Cross-referencesi

Sequence databases

RefSeqiXP_001605157.1. XM_001605107.3.
XP_008211006.1. XM_008212784.1.
XP_008211007.1. XM_008212785.1.
XP_008211008.1. XM_008212786.1.

3D structure databases

ProteinModelPortaliK7J699.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiNV16898-RA; NV16898-PA; NV16898.
GeneIDi100119291.
KEGGinvi:100119291.

Phylogenomic databases

InParanoidiK7J699.
KOiK00025.
PhylomeDBiK7J699.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR011274. Malate_DH_NAD-dep_euk.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
TIGR01758. MDH_euk_cyt. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional and evolutionary insights from the genomes of three parasitoid Nasonia species."
    Nasonia Genome Working Group
    Werren J.H., Richards S., Desjardins C.A., Niehuis O., Gadau J., Colbourne J.K., Werren J.H., Richards S., Desjardins C.A., Niehuis O., Gadau J., Colbourne J.K., Beukeboom L.W., Desplan C., Elsik C.G., Grimmelikhuijzen C.J., Kitts P., Lynch J.A.
    , Murphy T., Oliveira D.C., Smith C.D., van de Zande L., Worley K.C., Zdobnov E.M., Aerts M., Albert S., Anaya V.H., Anzola J.M., Barchuk A.R., Behura S.K., Bera A.N., Berenbaum M.R., Bertossa R.C., Bitondi M.M., Bordenstein S.R., Bork P., Bornberg-Bauer E., Brunain M., Cazzamali G., Chaboub L., Chacko J., Chavez D., Childers C.P., Choi J.H., Clark M.E., Claudianos C., Clinton R.A., Cree A.G., Cristino A.S., Dang P.M., Darby A.C., de Graaf D.C., Devreese B., Dinh H.H., Edwards R., Elango N., Elhaik E., Ermolaeva O., Evans J.D., Foret S., Fowler G.R., Gerlach D., Gibson J.D., Gilbert D.G., Graur D., Grunder S., Hagen D.E., Han Y., Hauser F., Hultmark D., Hunter H.C. IV, Hurst G.D., Jhangian S.N., Jiang H., Johnson R.M., Jones A.K., Junier T., Kadowaki T., Kamping A., Kapustin Y., Kechavarzi B., Kim J., Kim J., Kiryutin B., Koevoets T., Kovar C.L., Kriventseva E.V., Kucharski R., Lee H., Lee S.L., Lees K., Lewis L.R., Loehlin D.W., Logsdon J.M. Jr., Lopez J.A., Lozado R.J., Maglott D., Maleszka R., Mayampurath A., Mazur D.J., McClure M.A., Moore A.D., Morgan M.B., Muller J., Munoz-Torres M.C., Muzny D.M., Nazareth L.V., Neupert S., Nguyen N.B., Nunes F.M., Oakeshott J.G., Okwuonu G.O., Pannebakker B.A., Pejaver V.R., Peng Z., Pratt S.C., Predel R., Pu L.L., Ranson H., Raychoudhury R., Rechtsteiner A., Reese J.T., Reid J.G., Riddle M., Robertson H.M., Romero-Severson J., Rosenberg M., Sackton T.B., Sattelle D.B., Schluns H., Schmitt T., Schneider M., Schuler A., Schurko A.M., Shuker D.M., Simoes Z.L., Sinha S., Smith Z., Solovyev V., Souvorov A., Springauf A., Stafflinger E., Stage D.E., Stanke M., Tanaka Y., Telschow A., Trent C., Vattathil S., Verhulst E.C., Viljakainen L., Wanner K.W., Waterhouse R.M., Whitfield J.B., Wilkes T.E., Williamson M., Willis J.H., Wolschin F., Wyder S., Yamada T., Yi S.V., Zecher C.N., Zhang L., Gibbs R.A.
    Science 327:343-348(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AsymCXImported.
  2. EnsemblMetazoa
    Submitted (MAR-2014) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiK7J699_NASVI
AccessioniPrimary (citable) accession number: K7J699
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: January 7, 2015
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.