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Protein

Histone-lysine N-methyltransferase

Gene

LOC100123008

Organism
Nasonia vitripennis (Parasitic wasp)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei182S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:LOC100123008Imported
OrganismiNasonia vitripennis (Parasitic wasp)Imported
Taxonomic identifieri7425 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaTerebrantesChalcidoideaPteromalidaePteromalinaeNasonia
Proteomesi
  • UP000002358 Componenti: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi7425.NV11709-PA.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 248SETInterPro annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 139S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni209 – 210S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1085. Eukaryota.
COG2940. LUCA.
InParanoidiK7IRL1.
KOiK11428.
OMAiHYCIDAT.
PhylomeDBiK7IRL1.

Family and domain databases

InterProiView protein in InterPro
IPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

K7IRL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVKNCPEPL EGLDDAAIRS SATPHRINMP SAEEEELLRN GNKRRGVAAD
60 70 80 90 100
DRKDQPDKLI KLPGPRVRKQ SNLALARAPI VSPKIITDNH KLTEYFPVRR
110 120 130 140 150
SVRKCKKAVL EERQRDLENK VLCGVEDGLQ VRHFPGKGRG VVTTRDFVKG
160 170 180 190 200
EYVVEYIGEL IDQMTAKKRE AKYAKDQNAG CYMYYFQHRN QQYCVDATAE
210 220 230 240 250
SEKLGRLVNH SRNGNLATRI VEIGSIPHLV LIAKEDIPAG VEVSYDYGDR
260
SRESILNHPW LAS
Length:263
Mass (Da):29,774
Last modified:January 9, 2013 - v1
Checksum:i0E10CB80EE582F83
GO

Sequence databases

RefSeqiXP_001606615.1. XM_001606565.4.

Genome annotation databases

EnsemblMetazoaiNV11709-RA; NV11709-PA; NV11709.
GeneIDi100123008.
KEGGinvi:100123008.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiK7IRL1_NASVI
AccessioniPrimary (citable) accession number: K7IRL1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: June 7, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported