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Protein
Submitted name:

Coagulation factor XIII A chain

Gene

F13A1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Ca2+UniRule annotationNote: Binds 1 Ca2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei318UniRule annotation1
Active sitei377UniRule annotation1
Active sitei400UniRule annotation1
Metal bindingi440CalciumUniRule annotation1
Metal bindingi442CalciumUniRule annotation1
Metal bindingi489CalciumUniRule annotation1
Metal bindingi494CalciumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-SSC-114608 Platelet degranulation
R-SSC-140875 Common Pathway of Fibrin Clot Formation

Names & Taxonomyi

Protein namesi
Submitted name:
Coagulation factor XIII A chainImported
Submitted name:
Coagulation factor XIII, A1 polypeptideImported
Gene namesi
Name:F13A1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 7

Expressioni

Gene expression databases

BgeeiENSSSCG00000024310

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000030183

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 403TGcInterPro annotationAdd BLAST94

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
GeneTreeiENSGT00760000119108
KOiK03917
OMAiCEEDAVY
OrthoDBiEOG091G030K
TreeFamiTF324278

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR034810 Factor_XIII_A
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PANTHERiPTHR11590:SF42 PTHR11590:SF42, 1 hit
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

Sequencei

Sequence statusi: Complete.

K7GQL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETPGTGAA FGGRRALPPN TSNAEENDPP TVELQGGLMP RGFNPQDYLN
60 70 80 90 100
VTDVHLFKER WDSNKVDHHT DKYDSKKLIV RRGQPFYIQI DFSRPYDPRR
110 120 130 140 150
DLFRVEYVIG RYPQENKGTY IPVPIVSELQ RGKWGAKVIT TEDRSVRLSV
160 170 180 190 200
QPSPDCIVGK FRMYVAVWTP YGVIRTSRNP ETDTYILFNP WCEEDAVYLD
210 220 230 240 250
NDKEREEYVL NDIGVIFYGE FNDIKSRSWS YGQFEEGILD ACLYMMDRAK
260 270 280 290 300
MDLSGRGNPI KVSRVGSAMV NAKDDEGVLV GSWDNVYSYG VPPSAWTGSV
310 320 330 340 350
DILLEYKSSQ TPVRYGQCWV FAGVFNTFLR CLGIPARVVT NYFSAHDNNA
360 370 380 390 400
NLQLDIFLEE DGNVNSKLTK DSVWNYHCWN EAWMTRPDLP VGFGGWQVVD
410 420 430 440 450
STPQENSDGM YRCGPASVQA IKHGHVCFQF DAPFVFAEVN SDVIYITAKK
460 470 480 490 500
DGTHVVKTLD TTHIGKLIVT KQVGADGMKD ITDTYKFQEG QEEERLALET
510 520 530 540 550
ALMYGAKKPL STEGIPKSRS DIHMDFEVER AVLGRDFKVV LTFRNNSPTR
560 570 580 590 600
YSVTAYLSGN ITFYTGVSKG EFKNETFNVT LEPLSFKTEA VWVRAGEYMG
610 620 630 640 650
QLLEQAFLHF FVTARVNETN DVLAKQKSVV LTIPKISVKV RGTQAVGSDM
660 670 680 690 700
VVTVEFTNPL NEPLQNVWMR LDGPGVTRPL RKIFREIRPN ATVQWEEVCR
710 720 730
PWVSGPRKLM ASMTSDSLRH VYGELNLHIQ RRPSV
Length:735
Mass (Da):83,344
Last modified:January 9, 2013 - v1
Checksum:i2C80EE7A0885EA42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000051 Genomic DNA No translation available.
GACC01000324 mRNA Translation: JAA74260.1
RefSeqiXP_001927665.3, XM_001927630.6
UniGeneiSsc.26345

Genome annotation databases

EnsembliENSSSCT00000035671; ENSSSCP00000030183; ENSSSCG00000024310
GeneIDi100153504
KEGGissc:100153504

Similar proteinsi

Entry informationi

Entry nameiK7GQL2_PIG
AccessioniPrimary (citable) accession number: K7GQL2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: May 23, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health