Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase

Gene

MATK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:MATKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000007264.13.
HGNCiHGNC:6906. MATK.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007264.

PTM / Processingi

Proteomic databases

MaxQBiK7ES68.
PeptideAtlasiK7ES68.
PRIDEiK7ES68.

Expressioni

Gene expression databases

BgeeiENSG00000007264.
ExpressionAtlasiK7ES68. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliK7ES68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 83SH2InterPro annotationAdd BLAST73
Domaini150 – 267Protein kinaseInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119011.

Family and domain databases

CDDicd09937. SH2_csk_like. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR035026. CSK.
IPR035027. Csk-like_SH2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
PANTHERiPTHR24418:SF307. PTHR24418:SF307. 1 hit.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Fragment.

K7ES68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SADPKLSLMP WFHGKISGQE AVQQLQPPED GLFLVRESAR HPGDYVLCVS
60 70 80 90 100
FGRDVIHYRV LHRDGHLTID EAVFFCNLMD MVERPPGNGT GCWGSPPWGW
110 120 130 140 150
AHGCPTILQH YSKDKGAICT KLVRPKRKHG TKSAEEELAR AGWLLNLQHL
160 170 180 190 200
TLGAQIGEGE FGAVLQGEYL GQKVAVKNIK CDVTAQAFLD ETAVMTKMQH
210 220 230 240 250
ENLVRLLGVI LHQGLYIVME HVSKGNLVNF LRTRGRALVN TAQLLQFSLH
260
VAEGMEYLES KKLVHRD
Length:267
Mass (Da):29,821
Last modified:January 9, 2013 - v1
Checksum:i8795F6F6E0796853
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei267Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005777 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000590493; ENSP00000468576; ENSG00000007264.
UCSCiuc060rsi.1. human.

Similar proteinsi

Entry informationi

Entry nameiK7ES68_HUMAN
AccessioniPrimary (citable) accession number: K7ES68
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: October 25, 2017
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported