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Protein

V-type proton ATPase subunit a

Gene

ATP6V0A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:ATP6V0A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000033627.14.
HGNCiHGNC:865. ATP6V0A1.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000033627.

PTM / Processingi

Proteomic databases

MaxQBiK7EN36.
PeptideAtlasiK7EN36.
PRIDEiK7EN36.

Expressioni

Gene expression databases

BgeeiENSG00000033627.
ExpressionAtlasiK7EN36. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliK7EN36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 54Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000004941.

Family and domain databases

InterProiView protein in InterPro
IPR002490. V-ATPase_116kDa_su.
PANTHERiPTHR11629. PTHR11629. 2 hits.
PfamiView protein in Pfam
PF01496. V_ATPase_I. 1 hit.

Sequencei

Sequence statusi: Fragment.

K7EN36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ANIPIMDTGE NPEVPFPRDM IDLEANFEKI ENELKEINTN QEALKRNFLE
60 70 80 90 100
LTELKFILRK TQQFFDEMAD PDLLEESSSL LEPSEMGRGT PLRLGFVAGV
110 120 130 140 150
INRERIPTFE RMLWRVCRGN VFLRQAEIEN PLEDPVTVES HSVVQARVQW
160 170 180 190
RDLGSPQPPL PGFKRFSCLS LPSSWGLQGD YVHKSVFIIF FQGDQ
Length:195
Mass (Da):22,451
Last modified:January 9, 2013 - v1
Checksum:i9C5B01F03E8B0DCB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei195Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067852 Genomic DNA. No translation available.
AC107993 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000592324; ENSP00000466767; ENSG00000033627.
UCSCiuc060fiy.1. human.

Similar proteinsi

Entry informationi

Entry nameiK7EN36_HUMAN
AccessioniPrimary (citable) accession number: K7EN36
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: October 25, 2017
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported