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Protein

Signal transducer and activator of transcription

Gene

STAT5A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:STAT5AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000126561.16
HGNCiHGNC:11366 STAT5A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126561

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

EPDiK7EK35
MaxQBiK7EK35
PeptideAtlasiK7EK35
PRIDEiK7EK35

Expressioni

Gene expression databases

BgeeiENSG00000126561
ExpressionAtlasiK7EK35 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7EK35
SMRiK7EK35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini558 – 655SH2InterPro annotationAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili148 – 168Sequence analysisAdd BLAST21
Coiled coili215 – 235Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236

Family and domain databases

Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR035858 STAT5a/5b
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 2 hits
PTHR11801:SF47 PTHR11801:SF47, 2 hits
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

K7EK35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN
60 70 80 90 100
PQDRAQATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQKTYDR
110 120 130 140 150
CPLELVRCIR HILYNEQRLV REANNCSSPA GILVDAMSQK HLQINQTFEE
160 170 180 190 200
LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFAQLA QLSPQERLSR
210 220 230 240 250
ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD
260 270 280 290 300
ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC
310 320 330 340 350
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA
360 370 380 390 400
TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC
410 420 430 440 450
CVMEYHQATG TLSAHFRNMS LKRIKRADRR GAESVTEEKF TVLFESQFSV
460 470 480 490 500
GSNELVFQVK GRVPFAVPDK VLWPQLCEAL NMKFKAEVQS NRGLTKENLV
510 520 530 540 550
FLAQKLFNNS SSHLEDYSGL SVSWSQFNRE NLPGWNYTFW QWFDGVMEVL
560 570 580 590 600
KKHHKPHWND GAILGFVNKQ QAHDLLINKP DGTFLLRFSD SEIGGITIAW
610 620 630 640 650
KFDSPERNLW NLKPFTTRDF SIRSLADRLG DLSYLIYVFP DRPKDEVFSK
660 670 680 690 700
YYTPVLAKAV DGYVKPQIKQ VVPEFVNASA DAGGSSATYM DQAPSPAVCP
710 720 730 740 750
QAPYNMYPQN PDHVLDQDGE FDLDETMDVA RHVEELLRRP MDSLDSRLSP
760
PAGLFTSARG SLS
Length:763
Mass (Da):87,362
Last modified:January 9, 2013 - v1
Checksum:iC7B1D8A7DDFFE969
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087691 Genomic DNA No translation available.
AC099811 Genomic DNA No translation available.
RefSeqiNP_001275649.1, NM_001288720.1
UniGeneiHs.437058

Genome annotation databases

EnsembliENST00000588868; ENSP00000465437; ENSG00000126561
GeneIDi6776
UCSCiuc010cyb.3 human

Similar proteinsi

Entry informationi

Entry nameiK7EK35_HUMAN
AccessioniPrimary (citable) accession number: K7EK35
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: April 25, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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