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K7D1J2

- K7D1J2_PANTR

UniProt

K7D1J2 - K7D1J2_PANTR

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Protein

Histone deacetylase

Gene

HDAC1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. core promoter binding Source: Ensembl
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  7. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  8. RNA polymerase II transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. ATP-dependent chromatin remodeling Source: Ensembl
  2. negative regulation by host of viral transcription Source: Ensembl
  3. negative regulation of androgen receptor signaling pathway Source: Ensembl
  4. positive regulation of cell proliferation Source: Ensembl
  5. positive regulation of receptor biosynthetic process Source: Ensembl
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Name:HDAC1Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. NuRD complex Source: Ensembl
  3. Sin3 complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

K7D1J2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK
60 70 80 90 100
MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC
110 120 130 140 150
PVFDGLFEFC QLSTGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF
160 170 180 190 200
CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK
210 220 230 240 250
YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVMSKVME
260 270 280 290 300
MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG
310 320 330 340 350
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM
360 370 380 390 400
TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEED
410 420 430 440 450
PDKRISICSS DKRIACEEEF SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE
460 470 480
KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK LA
Length:482
Mass (Da):55,117
Last modified:January 9, 2013 - v1
Checksum:iAC24B7C037D3490C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GABC01010028 mRNA. Translation: JAA01310.1.
GABF01008217 mRNA. Translation: JAA13928.1.
GABD01006993 mRNA. Translation: JAA26107.1.
GABE01009974 mRNA. Translation: JAA34765.1.
RefSeqiXP_001163573.2. XM_001163573.2.

Genome annotation databases

GeneIDi748850.
KEGGiptr:748850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GABC01010028 mRNA. Translation: JAA01310.1 .
GABF01008217 mRNA. Translation: JAA13928.1 .
GABD01006993 mRNA. Translation: JAA26107.1 .
GABE01009974 mRNA. Translation: JAA34765.1 .
RefSeqi XP_001163573.2. XM_001163573.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 748850.
KEGGi ptr:748850.

Phylogenomic databases

KOi K06067.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
    Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adipose stromalImported, Skeletal muscleImported, SkinImported and Smooth vascularImported.

Entry informationi

Entry nameiK7D1J2_PANTR
AccessioniPrimary (citable) accession number: K7D1J2
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: October 29, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)