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K7D1J2

- K7D1J2_PANTR

UniProt

K7D1J2 - K7D1J2_PANTR

Protein

Histone deacetylase

Gene

HDAC1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 10 (01 Oct 2014)
      Sequence version 1 (09 Jan 2013)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

    GO - Molecular functioni

    1. core promoter binding Source: Ensembl
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    6. RNA polymerase II transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. negative regulation by host of viral transcription Source: Ensembl
    2. negative regulation of androgen receptor signaling pathway Source: Ensembl
    3. positive regulation of cell proliferation Source: Ensembl
    4. positive regulation of receptor biosynthetic process Source: Ensembl
    5. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
    Gene namesi
    Name:HDAC1Imported
    OrganismiPan troglodytes (Chimpanzee)Imported
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. NuRD complex Source: Ensembl
    3. Sin3 complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    KOiK06067.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    K7D1J2-1 [UniParc]FASTAAdd to Basket

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    MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK    50
    MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC 100
    PVFDGLFEFC QLSTGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF 150
    CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK 200
    YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVMSKVME 250
    MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG 300
    GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM 350
    TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEED 400
    PDKRISICSS DKRIACEEEF SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE 450
    KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK LA 482
    Length:482
    Mass (Da):55,117
    Last modified:January 9, 2013 - v1
    Checksum:iAC24B7C037D3490C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GABC01010028 mRNA. Translation: JAA01310.1.
    GABF01008217 mRNA. Translation: JAA13928.1.
    GABD01006993 mRNA. Translation: JAA26107.1.
    GABE01009974 mRNA. Translation: JAA34765.1.
    RefSeqiXP_001163573.2. XM_001163573.2.

    Genome annotation databases

    GeneIDi748850.
    KEGGiptr:748850.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GABC01010028 mRNA. Translation: JAA01310.1 .
    GABF01008217 mRNA. Translation: JAA13928.1 .
    GABD01006993 mRNA. Translation: JAA26107.1 .
    GABE01009974 mRNA. Translation: JAA34765.1 .
    RefSeqi XP_001163573.2. XM_001163573.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 748850.
    KEGGi ptr:748850.

    Phylogenomic databases

    KOi K06067.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
      Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Adipose stromalImported, Skeletal muscleImported, SkinImported and Smooth vascularImported.

    Entry informationi

    Entry nameiK7D1J2_PANTR
    AccessioniPrimary (citable) accession number: K7D1J2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2013
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)