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K7D1J2 (K7D1J2_PANTR) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. PIRNR PIRNR037913

Subcellular location

Nucleus By similarity PIRNR PIRNR037913.

Sequence similarities

Belongs to the histone deacetylase family. HD Type 1 subfamily. PIRNR PIRNR037913

Ontologies

Keywords
   Biological processTranscription
Transcription regulation PIRNR PIRNR037913
   Cellular componentNucleus PIRNR PIRNR037913
   Molecular functionChromatin regulator PIRNR PIRNR037913
Hydrolase SAAS SAAS000286 PIRNR PIRNR037913
Gene Ontology (GO)
   Biological_processnegative regulation by host of viral transcription

Inferred from electronic annotation. Source: Ensembl

negative regulation of androgen receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of receptor biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentNuRD complex

Inferred from electronic annotation. Source: Ensembl

Sin3 complex

Inferred from electronic annotation. Source: Ensembl

cytosol

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionNAD-dependent histone deacetylase activity (H3-K14 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K18 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K9 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H4-K16 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

RNA polymerase II transcription corepressor activity

Inferred from electronic annotation. Source: Ensembl

core promoter binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
K7D1J2 [UniParc].

Last modified January 9, 2013. Version 1.
Checksum: AC24B7C037D3490C

FASTA48255,117
        10         20         30         40         50         60 
MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN 

        70         80         90        100        110        120 
AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS 

       130        140        150        160        170        180 
AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG 

       190        200        210        220        230        240 
DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI 

       250        260        270        280        290        300 
FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG 

       310        320        330        340        350        360 
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE 

       370        380        390        400        410        420 
KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEED PDKRISICSS DKRIACEEEF 

       430        440        450        460        470        480 
SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK 


LA 

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References

[1]"De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Adipose stromal EMBL JAA01310.1, Skeletal muscle EMBL JAA34765.1, Skin EMBL JAA26107.1 and Smooth vascular EMBL JAA13928.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GABC01010028 mRNA. Translation: JAA01310.1.
GABF01008217 mRNA. Translation: JAA13928.1.
GABD01006993 mRNA. Translation: JAA26107.1.
GABE01009974 mRNA. Translation: JAA34765.1.
RefSeqXP_001163573.2. XM_001163573.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID748850.
KEGGptr:748850.

Phylogenomic databases

KOK06067.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Entry information

Entry nameK7D1J2_PANTR
AccessionPrimary (citable) accession number: K7D1J2
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: April 16, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)