ID   K6ZI16_PANTR            Unreviewed;       196 AA.
AC   K6ZI16;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE            EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
GN   Name=HDAC8 {ECO:0000313|EMBL:JAA04441.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000089865.1,
GN   ECO:0000313|VGNC:VGNC:111887};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA04441.1};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000089865.1, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|EMBL:JAA04441.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA04441.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT   mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000089865.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate
CC         + L-lysyl-[protein]; Xref=Rhea:RHEA:69172, Rhea:RHEA-COMP:9752,
CC         Rhea:RHEA-COMP:13707, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:35899, ChEBI:CHEBI:137954;
CC         Evidence={ECO:0000256|ARBA:ARBA00029357};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69173;
CC         Evidence={ECO:0000256|ARBA:ARBA00029357};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC         [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC         COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:61930; EC=3.5.1.98;
CC         Evidence={ECO:0000256|ARBA:ARBA00029372};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58197;
CC         Evidence={ECO:0000256|ARBA:ARBA00029372};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl-
CC         [protein]; Xref=Rhea:RHEA:58108, Rhea:RHEA-COMP:9752, Rhea:RHEA-
CC         COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:61930; Evidence={ECO:0000256|ARBA:ARBA00029349};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58109;
CC         Evidence={ECO:0000256|ARBA:ARBA00029349};
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC       subfamily. {ECO:0000256|ARBA:ARBA00006457}.
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DR   EMBL; AACZ04026470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04026471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04026472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04026473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04026474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01006897; JAA04441.1; -; mRNA.
DR   RefSeq; XP_003317568.1; XM_003317520.2.
DR   Ensembl; ENSPTRT00000087239.1; ENSPTRP00000089865.1; ENSPTRG00000051531.1.
DR   GeneID; 465712; -.
DR   KEGG; ptr:465712; -.
DR   CTD; 55869; -.
DR   VGNC; VGNC:111887; HDAC8.
DR   GeneTree; ENSGT00940000157843; -.
DR   OrthoDB; 1327607at2759; -.
DR   Proteomes; UP000002277; Chromosome X.
DR   Bgee; ENSPTRG00000051531; Expressed in fibroblast and 21 other cell types or tissues.
DR   GO; GO:0004407; F:histone deacetylase activity; IEA:InterPro.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR003084; His_deacetylse_1.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF39; HISTONE DEACETYLASE 8; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01271; HISDACETLASE.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN          73..186
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   196 AA;  22158 MW;  3BDAC6733660CD8A CRC64;
     MLTREHRCGR SEEQELEPWP SPKKARSRRW LRNGFKRKME EPEEPADSGQ SLVPVYIYSP
     EYVSMCDSLA KIPKRASMVH SLIEAYALHK QMRIVKPKVA SMEEMATFHT DAYLQHLQKV
     SQEGDDDHPD SIEYGLGYDC PATEGIFDYA AAIGGATITA AQCLIDGMCK VAINWSGGWH
     HAKKETCVYV ALYKAF
//