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Protein

Alpha-conotoxin TxIB

Gene
N/A
Organism
Conus textile (Cloth-of-gold cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Alpha-conotoxin TxIB is a subtype-specific blocker of alpha-6/alpha-3 beta-2 beta-3 nAChRs nicotinic acetylcholine receptors (nAChRs). It has an IC50 of 28.4 nM.1 Publication
Alpha-conotoxin TxIB(G) inhibits alpha-6/alpha-3 beta-2 beta-3 nAChRs nicotinic acetylcholine receptors (nAChRs) with an IC50 of 247 nM.1 Publication

Miscellaneous

Alpha-conotoxin TxIB and Alpha-conotoxin TxIB(G) affect neither the following neuronal AChR: alpha-6/alpha-3 beta-4 (CHRNA6/CHRNA3 CHRNB4), alpha-7 (CHRNA7), alpha-9 alpha-10 (CHRNA9 CHRNA10), alpha-2 beta-2 (CHRNA2 CHRNB2), alpha-2 beta-4 (CHRNA2 CHRNB4), alpha-3 beta-2 (CHRNA3 CHRNB2), alpha-3 beta-4 (CHRNA3 CHRNB4), alpha-4 beta-2 (CHRNA4 CHRNB2), alpha-4 beta-4 (CHRNA4 CHRNB4), nor the muscle receptor alpha-1 beta-1 delta epsilon (CHRNA1 CHRNB1 CHRNE CHRND).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin TxIB
Cleaved into the following chain:
OrganismiConus textile (Cloth-of-gold cone)
Taxonomic identifieri6494 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00004259621 – 20By similarityAdd BLAST20
PeptideiPRO_000042596322 – 38Alpha-conotoxin TxIB(G)Add BLAST17
PeptideiPRO_000042596422 – 37Alpha-conotoxin TxIBAdd BLAST16
PropeptideiPRO_000042596539 – 41By similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 291 Publication
Disulfide bondi24 ↔ 371 Publication
Modified residuei37Cysteine amide; in Alpha-conotoxin TxIB1 Publication1
Modified residuei38Glycine amide; in Alpha-conotoxin TxIB(G)1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

Secondary structure

141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 25Combined sources3
Helixi27 – 29Combined sources3
Turni30 – 32Combined sources3
Turni34 – 36Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LZ5NMR-A22-37[»]
SMRiK4RNX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
IPR018072. Conotoxin_a-typ_CS.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.
PROSITEiView protein in PROSITE
PS60014. ALPHA_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

K4RNX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
FDGRNTSANN KATDLMALPV RGCCSDPPCR NKHPDLCGGR R
Length:41
Mass (Da):4,445
Last modified:January 9, 2013 - v1
Checksum:i85F2BDD62A31A281
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE995411 Genomic DNA. Translation: CCM73829.1.

Similar proteinsi

Entry informationi

Entry nameiCAIB_CONTE
AccessioniPrimary (citable) accession number: K4RNX9
Secondary accession number(s): L7MTK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: January 9, 2013
Last modified: November 22, 2017
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families