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K4QCJ7

- K4QCJ7_STREQ

UniProt

K4QCJ7 - K4QCJ7_STREQ

Protein

Thymidine kinase

Gene

tdk

Organism
Streptococcus dysgalactiae subsp. equisimilis AC-2713
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (09 Jan 2013)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Proton acceptorUniRule annotation
    Metal bindingi143 – 1431ZincUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi85 – 884ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    ORF Names:SDSE_0936Imported
    OrganismiStreptococcus dysgalactiae subsp. equisimilis AC-2713Imported
    Taxonomic identifieri759913 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000009215: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliK4QCJ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    K4QCJ7-1 [UniParc]FASTAAdd to Basket

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    MAQLYYKYGT MNSGKTIEIL KVAHNYEEQG KPVVIMTSAL DTRDGFGVVS    50
    SRIGMRREAV PISSDMDVFT FIDQLEEKPY CVLIDESQFL SKQNVYDLAR 100
    VVDKLNVPVM AFGLKNDFQN ELFEGSKYLL LLADKIDEIK TICQYCSKKA 150
    TMVLRTENGK PVYEGAQIQI GGNETYIPVC RKHYFHPPVS TEQSVMTEKK 200
    Length:200
    Mass (Da):22,744
    Last modified:January 9, 2013 - v1
    Checksum:i23D4D251366AD232
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE858529 Genomic DNA. Translation: CCI62433.1.
    RefSeqiYP_006904491.1. NC_019042.1.

    Genome annotation databases

    EnsemblBacteriaiCCI62433; CCI62433; SDSE_0936.
    GeneIDi13901370.
    KEGGisdc:SDSE_0936.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE858529 Genomic DNA. Translation: CCI62433.1 .
    RefSeqi YP_006904491.1. NC_019042.1.

    3D structure databases

    ProteinModelPortali K4QCJ7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCI62433 ; CCI62433 ; SDSE_0936 .
    GeneIDi 13901370.
    KEGGi sdc:SDSE_0936.

    Phylogenomic databases

    KOi K00857.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of a Streptococcus dysgalactiae subsp. equisimilis strain possessing Lancefield's group A antigen."
      Luetticken R., Bruellhoff K., Van der Linden M., Peltroche-Llacsahuanga H., Blom J., Weber-Lehmann J., Ferretti J.J., McShan W.M.
      Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AC-2713Imported.

    Entry informationi

    Entry nameiK4QCJ7_STREQ
    AccessioniPrimary (citable) accession number: K4QCJ7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2013
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3