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Protein

Dihydroorotate dehydrogenase

Gene

pyrD

Organism
Methanolobus psychrophilus R15
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

(S)-dihydroorotate + acceptor = orotate + reduced acceptor.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per subunit.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in the pathway UMP biosynthesis via de novo pathway, which is part of Pyrimidine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41SubstrateUniRule annotation1
Binding sitei122FMNUniRule annotation1
Binding sitei122SubstrateUniRule annotation1
Active sitei125NucleophileUniRule annotation1
Binding sitei160FMNUniRule annotation1
Binding sitei186FMN; via carbonyl oxygenUniRule annotation1
Binding sitei212FMN; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 42FMNUniRule annotation2
Nucleotide bindingi238 – 239FMNUniRule annotation2
Nucleotide bindingi260 – 261FMNUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processPyrimidine biosynthesisUniRule annotation
LigandFlavoprotein, FMNUniRule annotation

Enzyme and pathway databases

BioCyciMPSY1094980:G1HBJ-2320-MONOMER
UniPathwayiUPA00070

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenaseUniRule annotation (EC:1.3.-.-UniRule annotation)
Short name:
DHODUniRule annotation
Short name:
DHODaseUniRule annotation
Short name:
DHOdehaseUniRule annotation
Gene namesi
Name:pyrDUniRule annotation
ORF Names:Mpsy_2486Imported
OrganismiMethanolobus psychrophilus R15Imported
Taxonomic identifieri1094980 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanolobus
Proteomesi
  • UP000000459 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliK4MFJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 281DHO_dhInterPro annotationAdd BLAST279

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 69Substrate bindingUniRule annotation5
Regioni187 – 188Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK17828
OrthoDBiPOG093Z048X

Family and domain databases

CDDicd04740 DHOD_1B_like, 1 hit
Gene3Di2.30.26.10, 2 hits
3.20.20.70, 3 hits
HAMAPiMF_00224 DHO_dh_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR033888 DHOD_1B
IPR023359 Dihydro_DH_chainA_dom2
IPR005720 Dihydroorotate_DH
IPR024920 Dihydroorotate_DH_1
IPR012135 Dihydroorotate_DH_1_2
IPR001295 Dihydroorotate_DH_CS
PfamiView protein in Pfam
PF01180 DHO_dh, 1 hit
PIRSFiPIRSF000164 DHO_oxidase, 1 hit
TIGRFAMsiTIGR01037 pyrD_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS00912 DHODEHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

K4MFJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEITGIRLN NPTILAAGVM GTTGASLARI AWEGAGAVVT KSIGPEPKGG
60 70 80 90 100
HSNPSMIDLG YGFLNAMGLP NPSYPDFSGE IEIAKKEADV PVIASIFGGN
110 120 130 140 150
AQEFAIVADG LVDAGPDAFE LNVSCPHAQG YGASIGCDAC AVEEITAAVC
160 170 180 190 200
DITELPVWVK LTPNVTDIVS IGKAAQRGGA DAVVAINTVR GMAIDIHSGY
210 220 230 240 250
PVLGNRFGGL SGRAIKPVAI KCVYDLYAAL DIPIIGVGGI STWEDAVEMM
260 270 280 290 300
MAGASAVQIG SAVHDGPGIF QTVADGIESF MSSGGYRDTS DIVGLAHRRA
Length:300
Mass (Da):30,688
Last modified:January 9, 2013 - v1
Checksum:iF9653B99DF2B5D11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003083 Genomic DNA Translation: AFV24690.1
RefSeqiWP_015054396.1, NC_018876.1

Genome annotation databases

EnsemblBacteriaiAFV24690; AFV24690; Mpsy_2486
GeneIDi13843983
KEGGimpy:Mpsy_2486
PATRICifig|1094980.5.peg.2351

Similar proteinsi

Entry informationi

Entry nameiK4MFJ5_9EURY
AccessioniPrimary (citable) accession number: K4MFJ5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: February 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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