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Protein

Acetolactate synthase

Gene

Mpsy_0754

Organism
Methanolobus psychrophilus R15
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 pyruvate = 2-acetolactate + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
  • thiamine diphosphateUniRule annotationNote: Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (Mpsy_0754)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-valine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-valine from pyruvate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (Mpsy_0754)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation, Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

BioCyciMPSY1094980:G1HBJ-687-MONOMER
UniPathwayiUPA00047; UER00055
UPA00049; UER00059

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthaseUniRule annotation (EC:2.2.1.6UniRule annotation)
Gene namesi
ORF Names:Mpsy_0754Imported
OrganismiMethanolobus psychrophilus R15Imported
Taxonomic identifieri1094980 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanolobus
Proteomesi
  • UP000000459 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 174TPP_enzyme_NInterPro annotationAdd BLAST167
Domaini197 – 330TPP_enzyme_MInterPro annotationAdd BLAST134
Domaini389 – 536TPP_enzyme_CInterPro annotationAdd BLAST148

Sequence similaritiesi

Belongs to the TPP enzyme family.UniRule annotation

Phylogenomic databases

KOiK01652
OrthoDBiPOG093Z01J9

Family and domain databases

InterProiView protein in InterPro
IPR012846 Acetolactate_synth_lsu
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR029061 THDP-binding
IPR012000 Thiamin_PyroP_enz_cen_dom
IPR012001 Thiamin_PyroP_enz_TPP-bd_dom
IPR000399 TPP-bd_CS
IPR011766 TPP_enzyme-bd_C
PfamiView protein in Pfam
PF02775 TPP_enzyme_C, 1 hit
PF00205 TPP_enzyme_M, 1 hit
PF02776 TPP_enzyme_N, 1 hit
SUPFAMiSSF52467 SSF52467, 1 hit
SSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00118 acolac_lg, 1 hit
PROSITEiView protein in PROSITE
PS00187 TPP_ENZYMES, 1 hit

Sequencei

Sequence statusi: Complete.

K4M9M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSTERMTG ARALIECLYR EGVDTIFGYP GGVLLPIYDE LYSSNIRHIL
60 70 80 90 100
VRHEQAAAHA AEGYARATGK TGVCLATSGP GATNLVTGIA NAYMDSIPMV
110 120 130 140 150
ALTGQVPSSM IGNDAFQEAN ITGITMPITK HNYLVQDVKE LPRIIKEAFH
160 170 180 190 200
IASTGRPGPV LVDLPKDITT DMIDFYYPDK VELRGYNPTY QGNLQQIKKA
210 220 230 240 250
AVEIERSSKP VIYAGGGVIS ANAAAELKKL AEKIQAPVTT TLTGMGGFPG
260 270 280 290 300
NHPLFIGMPG MHGTKYANYA IQESDLLIAV GVRFDDRVTG KIKSFASNAK
310 320 330 340 350
IIHIDIDPAE ISKNVKVDIP IVGDAKWILS HIMKYTGKSQ SEEWLEKIEG
360 370 380 390 400
WKKQYPLHYM EPAGDEIKPQ YIVEQINAVC PDAIVVTEVG QHQMWAAQYF
410 420 430 440 450
KYTEPRTFIS SGGLGTMGYG FPAAIGAKVA RPDKVVIDVS GDGSFQMNSQ
460 470 480 490 500
EMATIVQNNI PVIIAIFNNG FLGMVRQWQE IFYGKRYSST CIRDSVDFVK
510 520 530 540 550
LAEAYGALGI RATKRDEVRP AIEKAIASGR PTLIDFIVEC EENVSPMVPA
560
GAAINEILDL ERKE
Length:564
Mass (Da):61,575
Last modified:January 9, 2013 - v1
Checksum:i22D25FE12D8BAFCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003083 Genomic DNA Translation: AFV22963.1
RefSeqiWP_015052686.1, NC_018876.1

Genome annotation databases

EnsemblBacteriaiAFV22963; AFV22963; Mpsy_0754
GeneIDi13844369
KEGGimpy:Mpsy_0754
PATRICifig|1094980.5.peg.695

Similar proteinsi

Entry informationi

Entry nameiK4M9M7_9EURY
AccessioniPrimary (citable) accession number: K4M9M7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: April 25, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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