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K4K7W0

- K4K7W0_HUMAN

UniProt

K4K7W0 - K4K7W0_HUMAN

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Protein
Submitted name:

Truncated breast and ovarian cancer susceptibility protein 2

Gene

BRCA2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. single-stranded DNA binding Source: InterPro

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell aging Source: Ensembl
  3. chromosome organization Source: Ensembl
  4. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
  5. double-strand break repair via homologous recombination Source: Ensembl
  6. female gonad development Source: Ensembl
  7. hemopoiesis Source: Ensembl
  8. inner cell mass cell proliferation Source: Ensembl
  9. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  10. male meiosis I Source: Ensembl
  11. oocyte maturation Source: Ensembl
  12. positive regulation of mitotic cell cycle Source: Ensembl
  13. regulation of cytokinesis Source: Ensembl
  14. replication fork protection Source: Ensembl
  15. response to gamma radiation Source: Ensembl
  16. response to UV-C Source: Ensembl
  17. response to X-ray Source: Ensembl
  18. spermatogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Truncated breast and ovarian cancer susceptibility protein 2Imported
Gene namesi
Name:BRCA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiK4K7W0. baseline and differential.

Family & Domainsi

Family and domain databases

InterProiIPR015252. BRCA2_hlx.
[Graphical view]
PfamiPF09169. BRCA-2_helical. 1 hit.
[Graphical view]
SUPFAMiSSF81872. SSF81872. 1 hit.

Sequencei

Sequence statusi: Fragment.

K4K7W0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20 
ALCDTPGVDP KLISRIWVYN HYR
Length:23
Mass (Da):2,717
Last modified:January 9, 2013 - v1
Checksum:iFC5083E07AAE1A21
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX480476 mRNA. Translation: AFU88818.1.
UniGeneiHs.34012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX480476 mRNA. Translation: AFU88818.1 .
UniGenei Hs.34012.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

ExpressionAtlasi K4K7W0. baseline and differential.

Family and domain databases

InterProi IPR015252. BRCA2_hlx.
[Graphical view ]
Pfami PF09169. BRCA-2_helical. 1 hit.
[Graphical view ]
SUPFAMi SSF81872. SSF81872. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of BRCA1/2 Founder Mutations in Southern Chinese Breast Cancer Patients Using Gene Sequencing and High Resolution DNA Melting Analysis."
    Kwong A., Ng E.K., Wong C.L., Law F.B., Au T., Wong H.N., Kurian A.W., West D.W., Ford J.M., Ma E.S.
    PLoS ONE 7:E43994-E43994(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiK4K7W0_HUMAN
AccessioniPrimary (citable) accession number: K4K7W0
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: October 29, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.