Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

K4K7W0

- K4K7W0_HUMAN

UniProt

K4K7W0 - K4K7W0_HUMAN

Protein
Submitted name:

Truncated breast and ovarian cancer susceptibility protein 2

Gene

BRCA2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. single-stranded DNA binding Source: InterPro

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cell aging Source: Ensembl
    3. chromosome organization Source: Ensembl
    4. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
    5. double-strand break repair via homologous recombination Source: Ensembl
    6. female gonad development Source: Ensembl
    7. hemopoiesis Source: Ensembl
    8. inner cell mass cell proliferation Source: Ensembl
    9. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
    10. male meiosis I Source: Ensembl
    11. oocyte maturation Source: Ensembl
    12. positive regulation of mitotic cell cycle Source: Ensembl
    13. regulation of cytokinesis Source: Ensembl
    14. replication fork protection Source: Ensembl
    15. response to gamma radiation Source: Ensembl
    16. response to UV-C Source: Ensembl
    17. response to X-ray Source: Ensembl
    18. spermatogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Truncated breast and ovarian cancer susceptibility protein 2Imported
    Gene namesi
    Name:BRCA2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiK4K7W0.

    Family & Domainsi

    Family and domain databases

    InterProiIPR015252. BRCA2_hlx.
    [Graphical view]
    PfamiPF09169. BRCA-2_helical. 1 hit.
    [Graphical view]
    SUPFAMiSSF81872. SSF81872. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    K4K7W0-1 [UniParc]FASTAAdd to Basket

    « Hide

    ALCDTPGVDP KLISRIWVYN HYR                                23
    Length:23
    Mass (Da):2,717
    Last modified:January 9, 2013 - v1
    Checksum:iFC5083E07AAE1A21
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JX480476 mRNA. Translation: AFU88818.1.
    UniGeneiHs.34012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JX480476 mRNA. Translation: AFU88818.1 .
    UniGenei Hs.34012.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi K4K7W0.

    Family and domain databases

    InterProi IPR015252. BRCA2_hlx.
    [Graphical view ]
    Pfami PF09169. BRCA-2_helical. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81872. SSF81872. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of BRCA1/2 Founder Mutations in Southern Chinese Breast Cancer Patients Using Gene Sequencing and High Resolution DNA Melting Analysis."
      Kwong A., Ng E.K., Wong C.L., Law F.B., Au T., Wong H.N., Kurian A.W., West D.W., Ford J.M., Ma E.S.
      PLoS ONE 7:E43994-E43994(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiK4K7W0_HUMAN
    AccessioniPrimary (citable) accession number: K4K7W0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2013
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 12 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.