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K4IU48 (K4IU48_BORAF) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL AFU74475.1
Synonyms:ddl HAMAP-Rule MF_00047
ORF Names:BafHLJ01_0209 EMBL AFU74475.1
OrganismBorrelia afzelii HLJ01 [Complete proteome] EMBL AFU74475.1
Taxonomic identifier1239934 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding167 – 22256ATP By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
K4IU48 [UniParc].

Last modified January 9, 2013. Version 1.
Checksum: DE83763B540709C0

FASTA30934,748
        10         20         30         40         50         60 
MKKNLMLIFG GVSFEHEISC KSAYSVYLAL LDLNKYNIYS VYIDKCTGIW YLLDSVSDPP 

        70         80         90        100        110        120 
KPIDTDVLPI VSLLPGFGIF SNNKNLEIDV VFPVVHGRTG EDGAIQGVLK VMDIPCVGAG 

       130        140        150        160        170        180 
IIGSAISSNK YFCKLLLKSF NIPIVPFIGF RQYDYSLDKE EIKRNVKEVL GYPIIVKPAV 

       190        200        210        220        230        240 
LGSSIGINVA YSENQIESCI EEALKYDLTI VIEKFIEARE IECSIIGNEK MKIFSPGEVV 

       250        260        270        280        290        300 
VQDFIFYDYD AKYSVIPGNS IIFNIPAHLE TNQLLSIKEY AFLVYKNLEL RGMARVDFFV 


EKKIRNNLS 

« Hide

References

[1]"Genome Sequence of Borrelia afzelii Strain HLJ01, Isolated from a Patient in China."
Jiang B.G., Zheng Y.C., Tong Y.G., Jia N., Huo Q.B., Fan H., Ni X.B., Ma L., Yang X.F., Jiang J.F., Cao W.C.
J. Bacteriol. 194:7014-7015(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HLJ01 EMBL AFU74475.1.
[2]Jiang B., Tong Y., Fan H., Jiang J.
Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HLJ01 EMBL AFU74475.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003882 Genomic DNA. Translation: AFU74475.1.
RefSeqYP_006931358.1. NC_018887.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFU74475; AFU74475; BafHLJ01_0209.
GeneID13852776.
KEGGbafh:BafHLJ01_0209.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK4IU48_BORAF
AccessionPrimary (citable) accession number: K4IU48
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: April 16, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)