Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-lactate dehydrogenase

Gene

101263923

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh), L-lactate dehydrogenase (101263923), L-lactate dehydrogenase (ldh2), L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei207Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:101263923Imported
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)Imported
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Chromosome 8

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiK4CIM9.

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc08g007420.2.1.

Structurei

3D structure databases

ProteinModelPortaliK4CIM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 174Ldh_1_NInterPro annotationAdd BLAST140
Domaini177 – 340Ldh_1_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
InParanoidiK4CIM9.
KOiK00016.
OMAiDQWKNIH.
OrthoDBiEOG09360DKP.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

K4CIM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSSSLSLD GLELNQVFFK SIANSNPPSQ TNHHTKISVI GVGNVGMAIA
60 70 80 90 100
QTILTQDLVD ELALVDANSD KLRGEMLDLQ HAAAFLPRTK IVASADYTVT
110 120 130 140 150
AGSDLCIVTA GARQNPGESR LNLLQRNLAM YKSIVPELVK YSPECILLIV
160 170 180 190 200
SNPVDVLTYV AWKLSGFPVN RVIGSGTNLD SSRFRFLIAD HLDVNAQDVQ
210 220 230 240 250
AYIVGEHGDS SVALWSSISV GGIPVLSFLE NQQIAFEKDT LEKIHKQVVQ
260 270 280 290 300
SAYEVINLKG YTSWAIGYSV ANLAFSIIRD QRRIHPVSIL AKGFYGIDGG
310 320 330 340
DVFLSLPAQL GRNGVLGVTN VHLTDEEIQQ LRNSAETILE VQNQLGI
Length:347
Mass (Da):37,645
Last modified:November 28, 2012 - v1
Checksum:i78AB93DDA6A06661
GO

Sequence databases

RefSeqiNP_001266020.2. NM_001279091.2.
UniGeneiLes.96.

Genome annotation databases

EnsemblPlantsiSolyc08g007420.2.1; Solyc08g007420.2.1; Solyc08g007420.2.
GeneIDi101263923.
GrameneiSolyc08g007420.2.1; Solyc08g007420.2.1; Solyc08g007420.2.
KEGGisly:101263923.

Similar proteinsi

Entry informationi

Entry nameiK4CIM9_SOLLC
AccessioniPrimary (citable) accession number: K4CIM9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: October 25, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported