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Protein
Submitted name:

Next to BRCA1 gene 1 protein

Gene

Nbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Next to BRCA1 gene 1 proteinImported
Gene namesi
Name:Nbr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:108498. Nbr1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiK3W4P1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017119.
ExpressionAtlasiK3W4P1. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliK3W4P1.
SMRiK3W4P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86PB1InterPro annotationAdd BLAST83
Domaini212 – 258ZZ-typeInterPro annotationAdd BLAST47
Domaini935 – 979UBAInterPro annotationAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili296 – 330Sequence analysisAdd BLAST35
Coiled coili720 – 740Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4351. Eukaryota.
KOG4582. Eukaryota.
ENOG4111TKN. LUCA.
GeneTreeiENSGT00390000016335.
OrthoDBiEOG091G0RGJ.

Family and domain databases

CDDicd14947. NBR1_like. 1 hit.
cd06396. PB1_NBR1. 1 hit.
InterProiView protein in InterPro
IPR032350. N_BRCA1_central.
IPR000270. PB1_dom.
IPR034852. PB1_NBR1.
IPR015940. UBA.
IPR009060. UBA-like_sf.
IPR000433. Znf_ZZ.
PfamiView protein in Pfam
PF16158. N_BRCA1_IG. 1 hit.
PF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
SMARTiView protein in SMART
SM00666. PB1. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiView protein in PROSITE
PS51745. PB1. 1 hit.
PS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

K3W4P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD
60 70 80 90 100
EENEEVKYDI QCEYEEALKM ANIKQGNQLQ MQVHEGYHVV DEALPKNVVE
110 120 130 140 150
NQAAARTGKK PLAHYSSLVR VLGSDMKTTE EPAPEQCSSA PCDTDQPQDK
160 170 180 190 200
PPDWFTSYLE MFREQVVKET VEKLEQRLQE KLVLQKPLLS SSPTEVSMPI
210 220 230 240 250
SEETLFLPEN QFSWHIACSH CQKRIVGVRY QCSLCPSYNI CEDCEAGPYT
260 270 280 290 300
HDTNHVLLKL RRPVVISSEP FFYSKYSAPR LPAALEQVRL QKQVDKNFVK
310 320 330 340 350
AEKQRLRAEK KQRKAEVKEL KKQLKLHRKI HLWNSIHGLQ SPKSPLGRPE
360 370 380 390 400
SLLQSNTLML PLQPCAPVMP TLSAAFVDEN LPDGTHLQPG TKFIKHWRMK
410 420 430 440 450
NTGNVKWNTD TKLKFMWGNL TLASTEKKDV LVPCLKAGHV GVVSVEFIAP
460 470 480 490 500
TLEGTYTSHW RLSHKGQQFG PRVWCSIIVD PFPSSESPDN VEGDRISSSK
510 520 530 540 550
ADDFSCEQEE AFLLAEEEIP LGEVTKQTEG TGASASQKTR RAASERELYI
560 570 580 590 600
PSVDLLTAQD LLSFELLDIN IVQELERVPH NTPVDMTPCM SPLPHDSPLI
610 620 630 640 650
EKPGLGQIQE ESEGAGFKAP PDSTVSAKRK AETPASVEET EEDLSGTQFV
660 670 680 690 700
CETVIRSLTL DAAPDHNPPC RQRSPQRELQ LYSTEGQQPL VLPGFCRKDS
710 720 730 740 750
SLKFALPEEG PRGDEREEIV HIVEEEVVEE EEEVQDEEVQ SQSSASSEDY
760 770 780 790 800
IIILPECFDT SRPLGDSMYS SALSQPGLER GAEGEPGIES GLEPTEARER
810 820 830 840 850
LPERESQPQE QSISDILTTS QPLDTVPLVP EVAGLPAALS RSAPCGQCES
860 870 880 890 900
SGVDSPGVDS PATMHEVPPA PDDIRGEPRG STGLANSRQR SCDHSRHHNG
910 920 930 940 950
SSIAGGLVKG ALSVAASAYK ALFSGPPVTA QPIVSEDQTT ALMAHLFEMG
960 970 980
FCDRQLNLRL LRKHNYNILQ VVTELLQVNN NDWYSHRY
Length:988
Mass (Da):110,108
Last modified:November 28, 2012 - v1
Checksum:i4D8CC5A5B8933FB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590994 Genomic DNA. No translation available.
AL590996 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000071537; ENSMUSP00000071467; ENSMUSG00000017119.

Similar proteinsi

Entry informationi

Entry nameiK3W4P1_MOUSE
AccessioniPrimary (citable) accession number: K3W4P1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: January 31, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported