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Protein

NAD kinase

Gene

nadK

Organism
Slackia piriformis YIT 12062
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Proton acceptorUniRule annotation1
Binding sitei71NADUniRule annotation1
Binding sitei151NADUniRule annotation1
Binding sitei168NADUniRule annotation1
Binding sitei170NADUniRule annotation1
Binding sitei205NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 67NADUniRule annotation2
Nucleotide bindingi140 – 141NADUniRule annotation2
Nucleotide bindingi181 – 186NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotationSAAS annotation (EC:2.7.1.23UniRule annotationSAAS annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
ORF Names:HMPREF9451_01115Imported
OrganismiSlackia piriformis YIT 12062Imported
Taxonomic identifieri742818 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCoriobacteriiaEggerthellalesEggerthellaceaeSlackia
Proteomesi
  • UP000006069 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.301 hit
3.40.50.103302 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

K0YVZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILIIRNNS NAAALDASML LAAYLDSQGV AHQELDSIPL SIESVKDTCS
60 70 80 90 100
HVDVSSFDMV VSLGGDGTML RTARLVGKTR VPILGINFGH LGFLVNSSED
110 120 130 140 150
GVVAIVAAAL AGDVVREERA SLHIDLIAHG EVVASRFALN EFSVTRGTLG
160 170 180 190 200
RIIDFGVDIS GNHLVDMRGD GLVVASATGS TAYALSAGGP LVAPDFKGLV
210 220 230 240 250
VVPLAPHTLL SRSIVTDPSD IVEIDLSRNP ESREASYFVD GEFITLEEPI
260 270 280
DRILVRKSNN PTILLRYKNE GFYSAVAHTF FADQRS
Length:286
Mass (Da):30,502
Last modified:November 28, 2012 - v1
Checksum:iAF7937F7065D224B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADMD01000007 Genomic DNA Translation: EJZ83599.1
RefSeqiWP_009139318.1, NZ_JH815198.1

Genome annotation databases

EnsemblBacteriaiEJZ83599; EJZ83599; HMPREF9451_01115
PATRICifig|742818.3.peg.1175

Similar proteinsi

Entry informationi

Entry nameiK0YVZ2_9ACTN
AccessioniPrimary (citable) accession number: K0YVZ2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: February 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported