Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

4-hydroxy-4-methyl-2-oxoglutarate aldolase

Gene

MFORT_16921

Organism
Mycobacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.UniRule annotationSAAS annotation

Catalytic activityi

4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate.UniRule annotationSAAS annotation
Oxaloacetate = pyruvate + CO2.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-4-methyl-2-oxoglutarate aldolaseUniRule annotationSAAS annotation (EC:4.1.1.3UniRule annotation, EC:4.1.3.17UniRule annotationSAAS annotation)
Short name:
HMG aldolaseUniRule annotation
Alternative name(s):
Oxaloacetate decarboxylaseUniRule annotation
Gene namesi
ORF Names:MFORT_16921Imported
OrganismiMycobacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841Imported
Taxonomic identifieri1214102 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006043 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homotrimer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class II aldolase/RraA-like family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H03SM.

Family and domain databases

CDDicd16841. RraA_family. 1 hit.
Gene3Di3.50.30.40. 1 hit.
InterProiView protein in InterPro
IPR010203. RraA.
IPR005493. RraA/RraA-like.
IPR036704. RraA/RraA-like_sf.
PfamiView protein in Pfam
PF03737. RraA-like. 1 hit.
SUPFAMiSSF89562. SSF89562. 1 hit.
TIGRFAMsiTIGR01935. NOT-MenG. 1 hit.

Sequencei

Sequence statusi: Complete.

K0VNN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIEPRATAD LVDEIYPDVR SCDLQLQNYG GRTMFAGPIT TVRCFQDNAL
60 70 80 90 100
LKSILSTPGD GGVLVVDGNG SLHTALVGDI IAGLAAEHGW SGVIVHGAVR
110 120 130 140 150
DAAALRTIDV GIKALGTNPR KGTKTGEGER DVEVSFGGVT FVPGEIAYAD
160
EDGIVVVGDD R
Length:161
Mass (Da):16,751
Last modified:November 28, 2012 - v1
Checksum:i0A54E12380299DCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ALQB01000068 Genomic DNA. Translation: EJZ12814.1.
RefSeqiWP_003883968.1. NZ_JH814746.1.

Genome annotation databases

EnsemblBacteriaiEJZ12814; EJZ12814; MFORT_16921.
PATRICifig|1214102.3.peg.3359.

Similar proteinsi

Entry informationi

Entry nameiK0VNN3_MYCFO
AccessioniPrimary (citable) accession number: K0VNN3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: October 25, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported