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K0NDZ0 (K0NDZ0_DESTT) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL CCK79156.1
Ordered Locus Names:TOL2_C09910 EMBL CCK79156.1
OrganismDesulfobacula toluolica (strain DSM 7467 / Tol2) [Complete proteome] [HAMAP] EMBL CCK79156.1
Taxonomic identifier651182 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacula

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain103 – 304202ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding131 – 18656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2591Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2711Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2711Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2731Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
K0NDZ0 [UniParc].

Last modified November 28, 2012. Version 1.
Checksum: 7790AE0319BDC374

FASTA31934,775
        10         20         30         40         50         60 
MEKIRLALLS GGVSSERQVS LSSGKQVLNA LDKSRYDITL YDPKTDLKQL VIDAEQIDAA 

        70         80         90        100        110        120 
LIILHGPFGE DGTVQGLLDL LDIPYQGAGV LGSAMAMNKL VAKRLYEGAK VPTPSYLSFS 

       130        140        150        160        170        180 
LTDKINFSAI VEAMDLPLVV KPACAGSSVG MSLVKQAKDL ESAVALGFAH DDCIIIEKYV 

       190        200        210        220        230        240 
KGIELTCGVL GNDTLEALPV IEIVPGKNHE FFDYTAKYTA GETKEICPAR IDETTRKKVQ 

       250        260        270        280        290        300 
ELAVKAHKAL FLKGYSRTDM ILHNTELLVL ETNTIPGMTA TSLYPQSAQV AGYTFTELLD 

       310 
RLIQLSIKEH TKQNLRRST 

« Hide

References

[1]"Complete genome, catabolic sub-proteomes and key-metabolites of Desulfobacula toluolica Tol2, a marine, aromatic compound-degrading, sulfate-reducing bacterium."
Wohlbrand L., Kube M., Mussmann M., Jarling R., Beck A., Amann R., Wilkes H., Reinhardt R., Rabus R.
Environ. Microbiol. 15:1334-1355(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 7467 / Tol2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO203503 Genomic DNA. Translation: CCK79156.1.
RefSeqYP_006759860.1. NC_018645.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCK79156; CCK79156; TOL2_C09910.
GeneID13679660.
KEGGdto:TOL2_C09910.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK0NDZ0_DESTT
AccessionPrimary (citable) accession number: K0NDZ0
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: June 11, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)