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K0MFB9

- K0MFB9_BORPB

UniProt

K0MFB9 - K0MFB9_BORPB

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Protein

Alanine racemase

Gene

alr

Organism
Bordetella parapertussis (strain Bpp5)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei144 – 1441SubstrateUniRule annotation
Active sitei272 – 2721Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei320 – 3201Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BN117_1406Imported
OrganismiBordetella parapertussis (strain Bpp5)Imported
Taxonomic identifieri1208660 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000008035: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliK0MFB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K0MFB9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLASDPFDA PIPGLHACID PIAVAHNLEV LRQRLGVGVD GPRIWATVKA
60 70 80 90 100
DAYGHGLHNV LPGLRAADGI AVRHLHEAHQ CRRVGWRGPI MVYAGLTHER
110 120 130 140 150
EAALLTLQQL HLVITDMTQL EWLPGKPLYA CAPWVWLRYI GATRLGGLDA
160 170 180 190 200
GEYRRAYARC RELQQHGALR GVGHLNHYAN AASVGDLERE HADFEACIRG
210 220 230 240 250
LPGPVSTCNS AASCVMPTMA ARTDWVRPGL ALYGVSPIPD RVGRDLGLRP
260 270 280 290 300
AMTLRSTLCA TQKLPAGASV GYGCAFVADQ PMALGLVRCG YGDGYPHNPR
310 320 330 340 350
ASFPVQVDGV LTRTVGRISM DLMAVDLRPI PAAARGAPVV LWGSPQLPVE
360 370 380
HIAHAADTIA AELLTGLTAR VPLMRADHAA LLRGPLA
Length:387
Mass (Da):41,465
Last modified:November 28, 2012 - v1
Checksum:i706F846FF0EF2A75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE965803 Genomic DNA. Translation: CCJ48739.1.
RefSeqiWP_015039330.1. NC_018828.1.
YP_006895388.1. NC_018828.1.

Genome annotation databases

EnsemblBacteriaiCCJ48739; CCJ48739; BN117_1406.
GeneIDi13889442.
KEGGibpar:BN117_1406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE965803 Genomic DNA. Translation: CCJ48739.1 .
RefSeqi WP_015039330.1. NC_018828.1.
YP_006895388.1. NC_018828.1.

3D structure databases

ProteinModelPortali K0MFB9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCJ48739 ; CCJ48739 ; BN117_1406 .
GeneIDi 13889442.
KEGGi bpar:BN117_1406.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens."
    Park J., Zhang Y., Buboltz A.M., Zhang X., Schuster S.C., Ahuja U., Liu M., Miller J.F., Sebaihia M., Bentley S.D., Parkhill J., Harvill E.T.
    BMC Genomics 13:545-545(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bpp5Imported.

Entry informationi

Entry nameiK0MFB9_BORPB
AccessioniPrimary (citable) accession number: K0MFB9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: October 29, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3