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Protein

Alanine racemase

Gene

alr

Organism
Bordetella parapertussis (strain Bpp5)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (dadX)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei144SubstrateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Active sitei272Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei320Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBPAR1208660:G1HD3-1422-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BN117_1406Imported
OrganismiBordetella parapertussis (strain Bpp5)Imported
Taxonomic identifieri1208660 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000008035 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliK0MFB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 376Ala_racemase_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01775

Family and domain databases

Gene3Di2.40.37.101 hit
3.20.20.101 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

K0MFB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLASDPFDA PIPGLHACID PIAVAHNLEV LRQRLGVGVD GPRIWATVKA
60 70 80 90 100
DAYGHGLHNV LPGLRAADGI AVRHLHEAHQ CRRVGWRGPI MVYAGLTHER
110 120 130 140 150
EAALLTLQQL HLVITDMTQL EWLPGKPLYA CAPWVWLRYI GATRLGGLDA
160 170 180 190 200
GEYRRAYARC RELQQHGALR GVGHLNHYAN AASVGDLERE HADFEACIRG
210 220 230 240 250
LPGPVSTCNS AASCVMPTMA ARTDWVRPGL ALYGVSPIPD RVGRDLGLRP
260 270 280 290 300
AMTLRSTLCA TQKLPAGASV GYGCAFVADQ PMALGLVRCG YGDGYPHNPR
310 320 330 340 350
ASFPVQVDGV LTRTVGRISM DLMAVDLRPI PAAARGAPVV LWGSPQLPVE
360 370 380
HIAHAADTIA AELLTGLTAR VPLMRADHAA LLRGPLA
Length:387
Mass (Da):41,465
Last modified:November 28, 2012 - v1
Checksum:i706F846FF0EF2A75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE965803 Genomic DNA Translation: CCJ48739.1
RefSeqiWP_015039330.1, NC_018828.1
YP_006895388.1, NC_018828.1

Genome annotation databases

EnsemblBacteriaiCCJ48739; CCJ48739; BN117_1406
GeneIDi13889442
KEGGibpar:BN117_1406

Similar proteinsi

Entry informationi

Entry nameiK0MFB9_BORPB
AccessioniPrimary (citable) accession number: K0MFB9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: February 28, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported