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K0ME19 (K0ME19_BORPB) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 5. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlB EMBL CCJ48267.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:BN117_0934 EMBL CCJ48267.1
OrganismBordetella parapertussis (strain Bpp5) [Complete proteome] [HAMAP] EMBL CCJ48267.1
Taxonomic identifier1208660 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella ›

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047 SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain104 – 307204ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding130 – 18556ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2611Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2741Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2741Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2761Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
K0ME19 [UniParc].

Last modified November 28, 2012. Version 1.
Checksum: 7B7B70E82F4FDE5C

FASTA32033,955
        10         20         30         40         50         60 
MSKQFGKVGV LYGGRSAERE VSLMSGKGVH EALLSAGVDA HLFDTGERSL ADLAAAGFER 

        70         80         90        100        110        120 
VFIALHGRYG EDGTLQGALE LLGIPYTGSG PLASSLSMDK IMTKRVWLQH GLPTPAFEVL 

       130        140        150        160        170        180 
GGSTELRLVP DRLGLPLILK PPHEGSTVGI TKVAGYSDMK AAYELAARFD AEVLAEQFIT 

       190        200        210        220        230        240 
GRELTVAVLG SGAAARALPV IEIVAPGGNY DYEHKYFSDD TQYFCPADLP ADLPADVAAD 

       250        260        270        280        290        300 
VAAVAERAYA ALGCEGWGRV DFILDRENRP WLLEMNTSPG MTGHSLVPMA ARAVGMSYAD 

       310        320 
LCVAILAEAA CKVRSPARQD

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References

[1]"Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens."
Park J., Zhang Y., Buboltz A.M., Zhang X., Schuster S.C., Ahuja U., Liu M., Miller J.F., Sebaihia M., Bentley S.D., Parkhill J., Harvill E.T.
BMC Genomics 13:545-545(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bpp5 EMBL CCJ48267.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		HE965803 Genomic DNA. Translation: CCJ48267.1.
RefSeqYP_006894943.1. NC_018828.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCJ48267; CCJ48267; BN117_0934.
GeneID13888970.
KEGGbpar:BN117_0934.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK0ME19_BORPB
AccessionPrimary (citable) accession number: K0ME19
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: April 3, 2013
This is version 5 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info