ID   K0JW90_SACES            Unreviewed;       994 AA.
AC   K0JW90;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=BN6_11270 {ECO:0000313|EMBL:CCH28453.1};
OS   Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC
OS   15066 / NRRL 15764).
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharothrix.
OX   NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH28453.1, ECO:0000313|Proteomes:UP000006281};
RN   [1] {ECO:0000313|EMBL:CCH28453.1, ECO:0000313|Proteomes:UP000006281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC   {ECO:0000313|Proteomes:UP000006281};
RX   PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA   Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA   Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT   "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT   comparison to the other completely sequenced Pseudonocardiaceae.";
RL   BMC Genomics 13:465-465(2012).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; HE804045; CCH28453.1; -; Genomic_DNA.
DR   RefSeq; WP_015098566.1; NC_019673.1.
DR   AlphaFoldDB; K0JW90; -.
DR   STRING; 1179773.BN6_11270; -.
DR   KEGG; sesp:BN6_11270; -.
DR   PATRIC; fig|1179773.3.peg.1130; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_300881_0_0_11; -.
DR   OrthoDB; 7294637at2; -.
DR   BioCyc; SESP1179773:BN6_RS05550-MONOMER; -.
DR   Proteomes; UP000006281; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd00110; LamG; 2.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 3.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF13385; Laminin_G_3; 3.
DR   SMART; SM00282; LamG; 3.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006281};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..994
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5038915333"
FT   DOMAIN          403..589
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   REGION          368..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   994 AA;  102742 MW;  02F1FC60ACF0752A CRC64;
     MRLLVTVLAL LLAGSSVAAA SGVAPSTSSI GVEHVLFKSG TGGYGCYRIP ALVRTASGAL
     LAFAEGRRSP SCADRGDIDL VVRRSTNDGR TWSPTRVVLR GFGDNPFAPY TRGNPAPVVD
     AQTGRVFLLS TSNPAVPGGE RLPWVQHSDD DGLTWSTSRQ IPASFAGSTR GWFATGPSHG
     VQLRNGNLVV GAHQGVDGHV YAGVLYSTDH GDTWHASTTP DSLVEGKLNP GEMSVAELPN
     GDVYVAGRNH IATGHHRTRA ISKDGGASVS ASTAIPTLTT PDVQGSVLAL RSGTLLFAGP
     SDPQDRKLMR IRHSTDNGVT WTAGGLVNGS RAGYSDLAEL TTGEIGLLYE GGEKFSADEI
     RFTRFTTQQA QVPGGTNPAG PATPAPGPTS PDVSPEANDA YVRGSVGGGL VGQADLPWTR
     SLDVGADDFT VSFSFKHNGS TADQALFWAY GQGGSVPQVW LRVAKSGQVV AWVQGSGGGA
     TTSVPGAFAD GAWHQLTLTR QAGQVTLAVD AASTSATGVA GVVGQVGGRT GIRLGARLDG
     ADPFTGTLKD FTLTRAGRVV ADLPLVTVDG AATATRTTVA ITDDLTGHCA DGTLLGGHRV
     PVAGKFGSAL DVDSTHPGAE VPYLAALDPG GRDFTYSLWF QHKGGADQAL LWAYGATAGK
     PSVWVRAQPG SDRLYGWVQT DVGQVAVQVK DGTDAAAFGD GKWHQLVLRR VGDRVELSVD
     GGAPAVATGL TGSVGGPLGV RVGSKPDGSD VLDGVLDDVK LDIAGVPVLR WGFDGQNTQA
     HDVVRVPAGP GTPDGSQRCN HAAVRGGAAT TAGAVGRGLA FDGVDDSVVV PYEPVDGADF
     AVSTSFKYSG GGDQVLVWAY GVGATERALW LRAQPSKDRL LAWVQTDAGA FGVAAEDPSA
     VAAFGDGKWH RAELRRTGDR LELSVDGVVS GRAEIRGSLN YSDGFAVDGF QLGARPDGAD
     RFKGALDEFR VERGGATLVH LPFEVVSGRE YVRG
//