ID   K0JKU9_BRAPL            Unreviewed;       469 AA.
AC   K0JKU9;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   ORFNames=WESB_2245 {ECO:0000313|EMBL:CCG57707.1};
OS   Brachyspira pilosicoli WesB.
OC   Bacteria; Spirochaetota; Spirochaetia; Brachyspirales; Brachyspiraceae;
OC   Brachyspira.
OX   NCBI_TaxID=1161918 {ECO:0000313|EMBL:CCG57707.1, ECO:0000313|Proteomes:UP000003759};
RN   [1] {ECO:0000313|EMBL:CCG57707.1, ECO:0000313|Proteomes:UP000003759}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WesB {ECO:0000313|EMBL:CCG57707.1};
RX   PubMed=22947175; DOI=10.1186/1471-2164-13-454;
RA   Mappley L.J., Black M.L., Abuoun M., Darby A.C., Woodward M.J.,
RA   Parkhill J., Turner A.K., Bellgard M.I., La T., Phillips N.D.,
RA   La Ragione R.M., Hampson D.J.;
RT   "Comparative genomics of Brachyspira pilosicoli strains: genome
RT   rearrangements, reductions and correlation of genetic compliment with
RT   phenotypic diversity.";
RL   BMC Genomics 13:454-454(2012).
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DR   EMBL; HE793032; CCG57707.1; -; Genomic_DNA.
DR   RefSeq; WP_014933822.1; NC_018604.1.
DR   AlphaFoldDB; K0JKU9; -.
DR   KEGG; bpw:WESB_2245; -.
DR   PATRIC; fig|1161918.5.peg.1761; -.
DR   HOGENOM; CLU_024620_1_0_12; -.
DR   OrthoDB; 308984at2; -.
DR   Proteomes; UP000003759; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:CCG57707.1};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..469
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003833741"
FT   DOMAIN          116..325
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          26..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          295..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..315
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   469 AA;  50519 MW;  898B98357E684806 CRC64;
     MSKLKLFLIL ASALLISCAN PNDPGDDGTG GGGTGTGGGT NKAGYVFPKG SLSQEEQQKD
     LDPDSTMKVL FEKNDPKIGS KFFRIPALVV TKKGTIIAAA DRRYDTPTDL GKGGIIDVVV
     KTSSDMGNTW SDAITVLKAT DSKSSYGDAF LMNAHDGSVL MGVVAEPGVQ NKADTWIFKS
     TDEGKTWAKI ATLGTGSALY KDGTANRGFG ASGQGLTLRY GQNKGKLMFA FFQWNSASGG
     SGLSVSSIMS SDNGASWTKT GSIKPDRPDN NIDETKAIEL SDGTILLNHR RSVSKGGRSW
     SKSTDGGQNW TSEGLDPEVN DPGNNADFAR YEFYGRPVKT SEYILMINSD GTANGTWFFN
     RKRHTIRLTE NEFNNGNPTQ AGKYAYTKML AKDGATRYSG YPTISVLPDG SIITLTEEET
     ATERPAGGQF GAGGDDYDII FRRFNLYWLS DGKEYVDYSK DALFQQPNP
//