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K0HWX1

- K0HWX1_9BURK

UniProt

K0HWX1 - K0HWX1_9BURK

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Protein

Kynureninase

Gene

kynU

Organism
Acidovorax sp. KKS102
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei99 – 991Pyridoxal phosphateUniRule annotation
Binding sitei170 – 1701Pyridoxal phosphateUniRule annotation
Binding sitei199 – 1991Pyridoxal phosphateUniRule annotation
Binding sitei202 – 2021Pyridoxal phosphateUniRule annotation
Binding sitei224 – 2241Pyridoxal phosphateUniRule annotation
Binding sitei258 – 2581Pyridoxal phosphateUniRule annotation
Binding sitei284 – 2841Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
ORF Names:C380_18720Imported
OrganismiAcidovorax sp. KKS102Imported
Taxonomic identifieri358220 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000006306: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei225 – 2251N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1334Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

K0HWX1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPITFQDCRT RDAQDPLRAL RDHFALPPGV IYLDGNSLGV APKAAAARVA
60 70 80 90 100
DVVTREWGTD LIKSWNTASW FDLPQRLGNQ LAPLIGAGKD EVVCTDSTSI
110 120 130 140 150
NLYKVLSAAL NIAREDSPAR KRIVSERSNF PTDLYIAEGL CKERGLELVL
160 170 180 190 200
VEPEEIAASL TSDVAVLMLT HVNYRTGAMH DMAAITAAAH AQGILCVWDL
210 220 230 240 250
AHSAGAVPVD LNGAGADFSI GCGYKYLNGG PGAPAFVWVH PRHANRPDLK
260 270 280 290 300
FMQPLSGWWG HAAPFAFTPD YQPAPGITRY LCGTQPIISL SALQCGLDVF
310 320 330 340 350
TAAQGLGGMA ALRTKSLALT DLFIQLVEER CAGHGLGLAT PRDHAQRGSQ
360 370 380 390 400
VCLTRDEGAG VGGQGSGAYA IVQALIARGV IGDFRAGSGA APDAGKGDGG
410 420 430 440
TGHKDILRFG FTPLYLGFED VWNAVEHMRQ VLESGEWQKA EFNQTHAVT
Length:449
Mass (Da):47,851
Last modified:November 28, 2012 - v1
Checksum:iEDF276613DC7A779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003872 Genomic DNA. Translation: AFU47438.1.
RefSeqiWP_015015401.1. NC_018708.1.
YP_006856076.1. NC_018708.1.

Genome annotation databases

EnsemblBacteriaiAFU47438; AFU47438; C380_18720.
GeneIDi13788168.
KEGGiack:C380_18720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003872 Genomic DNA. Translation: AFU47438.1 .
RefSeqi WP_015015401.1. NC_018708.1.
YP_006856076.1. NC_018708.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFU47438 ; AFU47438 ; C380_18720 .
GeneIDi 13788168.
KEGGi ack:C380_18720.

Phylogenomic databases

KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of Acidovorax sp. Strain KKS102, a Polychlorinated-Biphenyl Degrader."
    Ohtsubo Y., Maruyama F., Mitsui H., Nagata Y., Tsuda M.
    J. Bacteriol. 194:6970-6971(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KKS102Imported.

Entry informationi

Entry nameiK0HWX1_9BURK
AccessioniPrimary (citable) accession number: K0HWX1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: November 26, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3