Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

K0HWX1

- K0HWX1_9BURK

UniProt

K0HWX1 - K0HWX1_9BURK

Protein

Kynureninase

Gene

kynU

Organism
Acidovorax sp. KKS102
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (28 Nov 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei98 – 981Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei99 – 991Pyridoxal phosphateUniRule annotation
    Binding sitei170 – 1701Pyridoxal phosphateUniRule annotation
    Binding sitei199 – 1991Pyridoxal phosphateUniRule annotation
    Binding sitei202 – 2021Pyridoxal phosphateUniRule annotation
    Binding sitei224 – 2241Pyridoxal phosphateUniRule annotation
    Binding sitei258 – 2581Pyridoxal phosphateUniRule annotation
    Binding sitei284 – 2841Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    ORF Names:C380_18720Imported
    OrganismiAcidovorax sp. KKS102Imported
    Taxonomic identifieri358220 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
    ProteomesiUP000006306: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei225 – 2251N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1334Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    K0HWX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPITFQDCRT RDAQDPLRAL RDHFALPPGV IYLDGNSLGV APKAAAARVA    50
    DVVTREWGTD LIKSWNTASW FDLPQRLGNQ LAPLIGAGKD EVVCTDSTSI 100
    NLYKVLSAAL NIAREDSPAR KRIVSERSNF PTDLYIAEGL CKERGLELVL 150
    VEPEEIAASL TSDVAVLMLT HVNYRTGAMH DMAAITAAAH AQGILCVWDL 200
    AHSAGAVPVD LNGAGADFSI GCGYKYLNGG PGAPAFVWVH PRHANRPDLK 250
    FMQPLSGWWG HAAPFAFTPD YQPAPGITRY LCGTQPIISL SALQCGLDVF 300
    TAAQGLGGMA ALRTKSLALT DLFIQLVEER CAGHGLGLAT PRDHAQRGSQ 350
    VCLTRDEGAG VGGQGSGAYA IVQALIARGV IGDFRAGSGA APDAGKGDGG 400
    TGHKDILRFG FTPLYLGFED VWNAVEHMRQ VLESGEWQKA EFNQTHAVT 449
    Length:449
    Mass (Da):47,851
    Last modified:November 28, 2012 - v1
    Checksum:iEDF276613DC7A779
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003872 Genomic DNA. Translation: AFU47438.1.
    RefSeqiWP_015015401.1. NC_018708.1.
    YP_006856076.1. NC_018708.1.

    Genome annotation databases

    EnsemblBacteriaiAFU47438; AFU47438; C380_18720.
    GeneIDi13788168.
    KEGGiack:C380_18720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003872 Genomic DNA. Translation: AFU47438.1 .
    RefSeqi WP_015015401.1. NC_018708.1.
    YP_006856076.1. NC_018708.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFU47438 ; AFU47438 ; C380_18720 .
    GeneIDi 13788168.
    KEGGi ack:C380_18720.

    Phylogenomic databases

    KOi K01556.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of Acidovorax sp. Strain KKS102, a Polychlorinated-Biphenyl Degrader."
      Ohtsubo Y., Maruyama F., Mitsui H., Nagata Y., Tsuda M.
      J. Bacteriol. 194:6970-6971(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KKS102Imported.

    Entry informationi

    Entry nameiK0HWX1_9BURK
    AccessioniPrimary (citable) accession number: K0HWX1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2012
    Last sequence update: November 28, 2012
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3