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Protein

Kynureninase

Gene

kynU

Organism
Acidovorax sp. KKS102
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynU)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU)
  3. no protein annotated in this organism
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei99Pyridoxal phosphateUniRule annotation1
Binding sitei170Pyridoxal phosphateUniRule annotation1
Binding sitei199Pyridoxal phosphateUniRule annotation1
Binding sitei202Pyridoxal phosphateUniRule annotation1
Binding sitei224Pyridoxal phosphateUniRule annotation1
Binding sitei258Pyridoxal phosphateUniRule annotation1
Binding sitei284Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciASP358220:G1HB5-3791-MONOMER
UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
ORF Names:C380_18720Imported
OrganismiAcidovorax sp. KKS102Imported
Taxonomic identifieri358220 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000006306 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei225N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 312Aminotran_5InterPro annotationAdd BLAST234

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni130 – 133Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

KOiK01556
OrthoDBiPOG091H0D63

Family and domain databases

Gene3Di3.40.640.101 hit
3.90.1150.102 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

K0HWX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPITFQDCRT RDAQDPLRAL RDHFALPPGV IYLDGNSLGV APKAAAARVA
60 70 80 90 100
DVVTREWGTD LIKSWNTASW FDLPQRLGNQ LAPLIGAGKD EVVCTDSTSI
110 120 130 140 150
NLYKVLSAAL NIAREDSPAR KRIVSERSNF PTDLYIAEGL CKERGLELVL
160 170 180 190 200
VEPEEIAASL TSDVAVLMLT HVNYRTGAMH DMAAITAAAH AQGILCVWDL
210 220 230 240 250
AHSAGAVPVD LNGAGADFSI GCGYKYLNGG PGAPAFVWVH PRHANRPDLK
260 270 280 290 300
FMQPLSGWWG HAAPFAFTPD YQPAPGITRY LCGTQPIISL SALQCGLDVF
310 320 330 340 350
TAAQGLGGMA ALRTKSLALT DLFIQLVEER CAGHGLGLAT PRDHAQRGSQ
360 370 380 390 400
VCLTRDEGAG VGGQGSGAYA IVQALIARGV IGDFRAGSGA APDAGKGDGG
410 420 430 440
TGHKDILRFG FTPLYLGFED VWNAVEHMRQ VLESGEWQKA EFNQTHAVT
Length:449
Mass (Da):47,851
Last modified:November 28, 2012 - v1
Checksum:iEDF276613DC7A779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003872 Genomic DNA Translation: AFU47438.1
RefSeqiWP_015015401.1, NC_018708.1

Genome annotation databases

EnsemblBacteriaiAFU47438; AFU47438; C380_18720
KEGGiack:C380_18720
PATRICifig|358220.3.peg.3815

Similar proteinsi

Entry informationi

Entry nameiK0HWX1_9BURK
AccessioniPrimary (citable) accession number: K0HWX1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: April 25, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported