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K0HWX1

- K0HWX1_9BURK

UniProt

K0HWX1 - K0HWX1_9BURK

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Protein
Kynureninase
Gene
kynU, C380_18720
Organism
Acidovorax sp. KKS102
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei99 – 991Pyridoxal phosphate By similarityUniRule annotation
Binding sitei170 – 1701Pyridoxal phosphate By similarityUniRule annotation
Binding sitei199 – 1991Pyridoxal phosphate By similarityUniRule annotation
Binding sitei202 – 2021Pyridoxal phosphate By similarityUniRule annotation
Binding sitei224 – 2241Pyridoxal phosphate By similarityUniRule annotation
Binding sitei258 – 2581Pyridoxal phosphate By similarityUniRule annotation
Binding sitei284 – 2841Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotation
ORF Names:C380_18720Imported
OrganismiAcidovorax sp. KKS102Imported
Taxonomic identifieri358220 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000006306: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei225 – 2251N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1334Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

K0HWX1-1 [UniParc]FASTAAdd to Basket

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MPITFQDCRT RDAQDPLRAL RDHFALPPGV IYLDGNSLGV APKAAAARVA    50
DVVTREWGTD LIKSWNTASW FDLPQRLGNQ LAPLIGAGKD EVVCTDSTSI 100
NLYKVLSAAL NIAREDSPAR KRIVSERSNF PTDLYIAEGL CKERGLELVL 150
VEPEEIAASL TSDVAVLMLT HVNYRTGAMH DMAAITAAAH AQGILCVWDL 200
AHSAGAVPVD LNGAGADFSI GCGYKYLNGG PGAPAFVWVH PRHANRPDLK 250
FMQPLSGWWG HAAPFAFTPD YQPAPGITRY LCGTQPIISL SALQCGLDVF 300
TAAQGLGGMA ALRTKSLALT DLFIQLVEER CAGHGLGLAT PRDHAQRGSQ 350
VCLTRDEGAG VGGQGSGAYA IVQALIARGV IGDFRAGSGA APDAGKGDGG 400
TGHKDILRFG FTPLYLGFED VWNAVEHMRQ VLESGEWQKA EFNQTHAVT 449
Length:449
Mass (Da):47,851
Last modified:November 28, 2012 - v1
Checksum:iEDF276613DC7A779
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003872 Genomic DNA. Translation: AFU47438.1.
RefSeqiWP_015015401.1. NC_018708.1.
YP_006856076.1. NC_018708.1.

Genome annotation databases

EnsemblBacteriaiAFU47438; AFU47438; C380_18720.
GeneIDi13788168.
KEGGiack:C380_18720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003872 Genomic DNA. Translation: AFU47438.1 .
RefSeqi WP_015015401.1. NC_018708.1.
YP_006856076.1. NC_018708.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFU47438 ; AFU47438 ; C380_18720 .
GeneIDi 13788168.
KEGGi ack:C380_18720.

Phylogenomic databases

KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of Acidovorax sp. Strain KKS102, a Polychlorinated-Biphenyl Degrader."
    Ohtsubo Y., Maruyama F., Mitsui H., Nagata Y., Tsuda M.
    J. Bacteriol. 194:6970-6971(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KKS102Imported.

Entry informationi

Entry nameiK0HWX1_9BURK
AccessioniPrimary (citable) accession number: K0HWX1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: September 3, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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