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K0HW25

- K0HW25_PROAA

UniProt

K0HW25 - K0HW25_PROAA

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Protein
Thymidine kinase
Gene
tdk, PAC1_05505
Organism
Propionibacterium acnes C1
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi86 – 894ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:PAC1_05505Imported
OrganismiPropionibacterium acnes C1Imported
Taxonomic identifieri1234380 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000006305: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliK0HW25.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

K0HW25-1 [UniParc]FASTAAdd to Basket

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MAELVFHTGP MDSGKSTLAL QMDHAQSAHD RQGVRYAMHD RSGGARITSR    50
IGLSVEAVEV TDSLDLYQDI VSRLSRGGRI DYLICDEAQF YRTKQIDQLA 100
RVVDDLDIDV YCFGILADFR TELFPGSKRL VELADRVVEP PVSPLCWCGR 150
PATHNARIVD GKLVREGDQV GVGDIGGGSE IHYEVLCRRH HRQGITGEIS 200
RATLSEQTLP FDGSRS 216
Length:216
Mass (Da):23,926
Last modified:November 28, 2012 - v1
Checksum:iF6055E1F110118C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003877 Genomic DNA. Translation: AFU40856.1.
RefSeqiYP_006851087.1. NC_018707.1.

Genome annotation databases

EnsemblBacteriaiAFU40856; AFU40856; PAC1_05505.
GeneIDi13783090.
KEGGipacc:PAC1_05505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003877 Genomic DNA. Translation: AFU40856.1 .
RefSeqi YP_006851087.1. NC_018707.1.

3D structure databases

ProteinModelPortali K0HW25.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFU40856 ; AFU40856 ; PAC1_05505 .
GeneIDi 13783090.
KEGGi pacc:PAC1_05505.

Phylogenomic databases

KOi K00857.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient."
    Minegishi K., Aikawa C., Furukawa A., Watanabe T., Nakano T., Ogura Y., Ohtsubo Y., Kurokawa K., Hayashi T., Maruyama F., Nakagawa I., Eishi Y.
    Genome Announc. 1:E00016-12(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C1Imported.

Entry informationi

Entry nameiK0HW25_PROAA
AccessioniPrimary (citable) accession number: K0HW25
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: September 3, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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