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K0HVZ9

- K0HVZ9_9BURK

UniProt

K0HVZ9 - K0HVZ9_9BURK

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Protein

Alanine racemase

Gene

alr

Organism
Acidovorax sp. KKS102
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei130 – 1301SubstrateUniRule annotation
Active sitei256 – 2561Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei304 – 3041Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:C380_01445Imported
OrganismiAcidovorax sp. KKS102Imported
Taxonomic identifieri358220 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000006306: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliK0HVZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K0HVZ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRPIAATIH TTALHHNLAR VRQSVPDAKV WAVVKANAYG HGIERVYEGL
60 70 80 90 100
RGADGFALLD LAEAERVRHL GWRGPILLLE GVFEPRDLEL CSRLGLWHAV
110 120 130 140 150
HCDEQIDMLA AHKTQVPHRV FLKMNSGMNR LGFTPERYRA AWARLNALPQ
160 170 180 190 200
VDEISFMTHF SDADGPRGIA HQMAAFNAAA QDLPGERSLS NSAATLRHAQ
210 220 230 240 250
DAGVRADWVR AGIVVYGSAP DFPEHHAGHW GLQPTMTLST RLIATQQLQA
260 270 280 290 300
GDTVGYGSRF TADGPLTIGI AACGYADGYP RHCDTGTPVL VNGVRTRLVG
310 320 330 340 350
RVSMDMVTVD LTPLQQAGVD VGFGSEVTLW GRASNGVVLS IDEVAQAAGT
360 370
VGYELMCALA QRVPVVVDGG A
Length:371
Mass (Da):39,969
Last modified:November 28, 2012 - v1
Checksum:iFD9067B79A7B82D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003872 Genomic DNA. Translation: AFU44015.1.
RefSeqiWP_015012110.1. NC_018708.1.
YP_006852653.1. NC_018708.1.

Genome annotation databases

EnsemblBacteriaiAFU44015; AFU44015; C380_01445.
GeneIDi13785102.
KEGGiack:C380_01445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003872 Genomic DNA. Translation: AFU44015.1 .
RefSeqi WP_015012110.1. NC_018708.1.
YP_006852653.1. NC_018708.1.

3D structure databases

ProteinModelPortali K0HVZ9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFU44015 ; AFU44015 ; C380_01445 .
GeneIDi 13785102.
KEGGi ack:C380_01445.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of Acidovorax sp. Strain KKS102, a Polychlorinated-Biphenyl Degrader."
    Ohtsubo Y., Maruyama F., Mitsui H., Nagata Y., Tsuda M.
    J. Bacteriol. 194:6970-6971(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KKS102Imported.

Entry informationi

Entry nameiK0HVZ9_9BURK
AccessioniPrimary (citable) accession number: K0HVZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: October 29, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3