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Protein

Alanine racemase

Gene

alr

Organism
Acidovorax sp. KKS102
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei130SubstrateUniRule annotation1
Active sitei256Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei304Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciASP358220:G1HB5-284-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:C380_01445Imported
OrganismiAcidovorax sp. KKS102Imported
Taxonomic identifieri358220 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000006306 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliK0HVZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 368Ala_racemase_CInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01775
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

K0HVZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPIAATIH TTALHHNLAR VRQSVPDAKV WAVVKANAYG HGIERVYEGL
60 70 80 90 100
RGADGFALLD LAEAERVRHL GWRGPILLLE GVFEPRDLEL CSRLGLWHAV
110 120 130 140 150
HCDEQIDMLA AHKTQVPHRV FLKMNSGMNR LGFTPERYRA AWARLNALPQ
160 170 180 190 200
VDEISFMTHF SDADGPRGIA HQMAAFNAAA QDLPGERSLS NSAATLRHAQ
210 220 230 240 250
DAGVRADWVR AGIVVYGSAP DFPEHHAGHW GLQPTMTLST RLIATQQLQA
260 270 280 290 300
GDTVGYGSRF TADGPLTIGI AACGYADGYP RHCDTGTPVL VNGVRTRLVG
310 320 330 340 350
RVSMDMVTVD LTPLQQAGVD VGFGSEVTLW GRASNGVVLS IDEVAQAAGT
360 370
VGYELMCALA QRVPVVVDGG A
Length:371
Mass (Da):39,969
Last modified:November 28, 2012 - v1
Checksum:iFD9067B79A7B82D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003872 Genomic DNA Translation: AFU44015.1
RefSeqiWP_015012110.1, NC_018708.1

Genome annotation databases

EnsemblBacteriaiAFU44015; AFU44015; C380_01445
KEGGiack:C380_01445
PATRICifig|358220.3.peg.297

Similar proteinsi

Entry informationi

Entry nameiK0HVZ9_9BURK
AccessioniPrimary (citable) accession number: K0HVZ9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: June 20, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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